HN Shivakumar, et al., (2007), Fabricated & evaluation of pH sensitive Minitablets for chronotherapeutic delivery of theophylline using different coat weights of eudragit S-100 to be applied to the drug loaded core mini-tablets. The study showed that the coat weight of 10% weight gain was sufficient to impart an excellent gastro resistant property to the tablets for effective release of the dru...

The effect of Eudragit RSPO on the photostability venlafaxine in a physical mixture and as melt was studied. A validated ultra-high-performance liquid chromatography mass spectrometry method used to determine content alongside degradation products. most likely structures products were determined by spectrometry. samples evaluated before after exposure ultraviolet differential scanning calorimet...

Emulsion-solvent evaporation technique was used to prepare Diclofenac sodium (DS) loaded Kollidon® SR (KSR) microspheres. Cellulosic polymers (HPMC 6 cps, 15 cps) and polymethacrylic polymers (Eudragit E100, Eudragit RL PO, and Eudragit RS PO) were added with KSR at 10% wt/wt of KSR. The effect of these polymers on drug content, particle size, surface morphology and DS release rate was evaluate...

A floating type of dosage form of ranitidine hydrochloride in the form of microspheres capable of floating on simulated gastric fluid was prepared by solvent evaporation technique. Microspheres prepared with ethyl cellulose, Eudragit(®) RS100 alone or in combination were evaluated for percent yield, drug entrapment, percent buoyancy and drug release and the results demonstrated satisfactory per...

This study was carried out to evaluate the ocular performance of a cationic Eudragit (EDU) RS 100-coated nanostructured lipid carrier (NLC). The genistein encapsulated NLC (GEN-NLC) was produced using the melt-emulsification technique followed by surface absorption of EDU RS 100. The EDU RS 100 increased the surface zeta potential from -7.46 mV to +13.60 mV, by uniformly forming a spherical coa...

the most frequent adverse effects of indomethacin like other nsaids are gastro–intestinal and central nervous system disturbances. extended release or enteric release formulations minimize these symptoms. the objective of this study was to develop an extended release pellet formulation of indomethacin by the centrifugation (rotary fluid bed granulation) or powder layering method. layered, nonpa...

In the present work, paracetamol loaded eudragit based microsponges were prepared using quasi-emulsion solvent diffusion method. The compatibility of the drug with various formulation components was established. Process parameters were analyzed in order to optimize the formulation. Shape and surface morphology of the microsponges were examined using scanning electron microscopy. The formulation...

BACKGROUND AND THE PURPOSE OF THE STUDY Lercanidipine hydrochloride (LRDP) is used in the treatment of hypertension because of its selectivity and specificity on the smooth vascular cells. The pharmacokinetic parameters make LRDP a suitable candidate for transdermal delivery. The purpose of the study was to select a suitable formulation for the development of transdermal drug-delivery system (T...

The aspire of this attempt was to design and evaluate aceclofenac loaded sustained release microspheres by emulsion solvent evaporation method, using different polymers like Ethyl cellulose (EC), Kollidon SR (KSR), Eudragit RS 100, Eudragit RL 100 and Hydroxypropylmethyl Cellulose (HPMC K100M). Microspheres were prepared using different stirring rate (1200, 1500, 2000rpm) and larger microsphere...