Declaration of interest Thiswork was sponsoredby Eli Lilly & Co. Post-traumatic stress disorder (PTSD) is a psychopathological response to a terrifying experience. Initially associated with combat, PTSD is observed in civilians following traumatic experiences, including violence, accident, natural disaster and life-threatening illness. Lifetime prevalence of PTSD in civilians is between 1% and ...

an inhibitory modulator of cholinergic and noradrenergic neurotransmission (Miller et al., 1999; Van Hoomissen et al., 2004; Landry et al., 2005; Hobson et al., 2006). Gal is co-localized with norepinephrine (NE) in several regions of the brain, such as locus coeruleus, bed nucleus of the stria terminalis, amygdala, cortex and hippocampus (Hokfelt et al., 1998; Kozicz, 2001; Xu et al., 2001; Ho...

Following the works of Velazquez et al. (1999), Jo-Seung et al. (2000), Wang et al. (2001), Danscher et al. (2001) and the criteria of Zinc-containing neurons established by Frederickson et al.(2000), we have found the presence and localisation of Zinc in the neurons of the dorsal root ganglia of Wistar rat, by using Timm's thecnique and by studying the autoradiographic uptake of 65Zn. The agre...

A crucial topic for recreational drug research is the long-term effects of regular usage. With respect to cannabis, Solowij et al. (2002) noted: ‘One issue remains unresolved: does heavy, frequent or prolonged use of cannabis lead to a deterioration in cognitive function that persists well beyond any period of acute intoxication? Is the functioning of the brain altered in the long-term?’. Many ...

A number of antineoplastic drugs are used to combat with different types of cancer which have also shown to be mutagenic in various test systems. Various antineoplastic drugs such as cisplatin, cyclophosphamide, Tamoxifrn Genecitabine and Paclitaxel etc have shown to be clastogenic effects in various test systems (Garrone et al., 1993; Takeda et al., 2001; Padmalatha Rai and Vijaylakhmi, 2001; ...

Tetrazolium dyes have often been used as electron acceptors in measurements of cell proliferation rates (Berridge and Tan, 1993; Ishiyama, et al., 1993; Berridge, et al., 1996), in histochemical procedures (Zamudio, et al., 1969; May, et al., 1995b; Demehin, et al., 2001), and for assaying redox enzymes (Berridge and Tan, 1993; Mittler and Zilinskas, 1993; Debnam and Shearer, 1997; Ye, et al., ...

The complex series of molecular interactions between male and female gametes required for successful fertilization has captured the interest of several research groups for many years (Benoff 1997). Even though substantial insights into these interactions have been elucidated in particular in human and mouse (Fusi et al. 1992; 1996a; 1996b; Almeida et al. 1995; Evans et al. 1995; Bronson & Fusi ...

part of its information-gathering activity. The views, conclusions, and recommendations are not intended to represent the views of the Commission. part of its information-gathering activity. The views, conclusions, and recommendations are not intended to represent the views of the Commission. Disclaimer This is a working paper of the World Commission on Dams-the report published herein was prep...