Background: Breast cancer is an important cause of cancer death among women all over the world. Even in places with low incidence there are reports of an increase in the number of breast cancer patients. The aim of the present study was to report the demographic aspects of breast cancer among patients referred by surgeons for adjuvant therapy in a private cancer clinic during the past five year...

Estrogen receptor beta (ERβ) is an isoform of estrogen that plays a role in breast cancer. An E3 ubiquitin ligase, murine double minute 2 (MDM2), can bind to ERβ and degrade it. Virtual screening protein-protein docking studies are one the approaches be performed discover FDA-approved drugs targeting interaction ERβ-MDM2 complex. This study aimed conduct virtual 1615 compounds between as initia...

It has long been accepted that modern reproductive patterns are likely contributors to breast cancer susceptibility because of their influence on hormones such as estrogen and the importance of these hormones in breast cancer. We conducted a meta-analysis to assess whether this 'evolutionary mismatch hypothesis' can explain susceptibility to both estrogen receptor positive (ER-positive) and est...

Estrogen has been postulated as a contributor for lung cancer development and progression. We reviewed the current knowledge about the expression and prognostic implications of the estrogen receptors (ER) in lung cancer, the effect and signaling pathway of estrogen on lung cancer, the hormone replacement therapy and lung cancer risk and survival, the mechanistic relationship between the ER and ...

We have previously found that human breast cancer cells in tissue culture contain estrogen receptor in their nuclei despite the absence of estrogen. We have now investigated solid human breast cancer biopsies and find that proteolytic activities in extracts from the nuclear pellets of these biopsies interfere with or prevent the measurement of nuclear estrogen receptor when the protamine assay ...

Triple-Negative Breast Cancer After Breast-Conserving Surgery and Radiation I read with interest the article by Freedman et al investigating the results of radiation on the local control of triple receptor-negative (TN) breast cancer (negative estrogen [ER], progesterone [PR], and HER-2 receptors). The authors compared 3 different groups defined by receptor status as follows: Group 1: ER or PR ...

We have established an estrogen receptor- and progesterone receptor-negative, hormone-nonresponsive breast cancer cell line from a receptor-positive, hormone-responsive line grown under estrogen-free conditions. T47D breast cancer cells were cultured under estrogenized conditions (in phenol red-containing medium supplemented with whole fetal bovine serum) and cloned to produce line T47D:A18. Th...

The orphan receptor estrogen-related receptor a (ERRa) is a member of the nuclear receptor superfamily of ligand-regulated transcription factors. This protein is structurally most related to the canonical estrogen receptor and has been shown to modulate estrogen signaling in some contexts. These observations have heightened interest in ERRa as a therapeutic target in both breast and ovarian can...

Abstract Breast cancer is the most common with a high rate of mortality and morbidity among women worldwide. Estrogen receptor status an important prognostic factor endocrine therapy choice first-line treatment in ER-positive breast cancer. However, tumors develop resistance to therapy. Here we demonstrate that BH3 profiling technology, particular, dynamic can predict response agents as well de...