RNA interfering (RNAi) screening strategies offer the potential to elucidate the signaling pathways that regulate integrin and adhesion receptor-mediated changes in T lymphocyte morphology. Of crucial importance, however, is the definition of key sets of parameters that will provide accurate, quantitative, and nonredundant information to flag relevant hits in such assays. In this study, the aut...

While Civil War history is dominated by pivotal battles and campaigns like the Battle of Gettysburg or Sherman's March through Georgia, the greater part of the War efforts of both the Union and Confederate armies were expended in sustaining and moving large armies, in jockeying for position and in preparing for battle. It has been estimated that in the course of a year's service, the average so...

People-oriented landscape experiences have become the focus of park design with increasing demand outdoor activities from urban residents, whereas thermal-comfort-guided has attracted more attention in academic circles. Based on investigation microclimate typical subregions riverside parks, this paper uses AI recognition to analyze spatiotemporal distribution camping crowds, and considers corre...

Background: It is important to set up hospitals, since they play a key role in providing health care services based on the budget allocated to the health sector. Objective:  This study evaluated factors militating against the establishment of hospitals in Iran. It also emphasized the importance of health care services. Methods: This...

We demonstrate experimentally an optical process in which the spin angular momentum carried by a circularly polarized light beam is converted into orbital angular momentum, leading to the generation of helical modes with a wave-front helicity controlled by the input polarization. This phenomenon requires the interaction of light with matter that is both optically inhomogeneous and anisotropic. ...

Coordinated cell polarization and mitotic spindle orientation are thought to be important for epithelial morphogenesis. Whether spindle orientation is indeed linked to epithelial morphogenesis and how it is controlled at the molecular level is still unknown. Here, we show that the NuMA- and Galpha-binding protein LGN is required for directing spindle orientation during cystogenesis of MDCK cell...