نتایج جستجو برای: esr1 gene
تعداد نتایج: 1141824 فیلتر نتایج به سال:
چکیده مقدمه: جهش های ژنتیکی با توجه به نقش غیرقابل انکاری که در پیدایش بیماری ها داشته و با تاثیر بر روی کنش های بعدی بیماری، موجب آسیب های بدخیم در پستان می شوند. از آن جمله، جهش نقطه ای در ژن گیرنده استروژن α (esr1)، مانند g908a (لیزین 303 آرژنین) سبب تکثیر بی رویه سلول های حساس به استروژن و رشد تومور در پستان می شود. در این تحقیق ما به شناسایی و غربالگری این جهش در میان زنان ایرانی مبتلا به ...
AIM The aim of the study was to evaluate the use of global and gene-specific DNA methylation changes as potential biomarkers for gallbladder cancer (GBC) in a cohort from Chile. MATERIAL & METHODS DNA methylation was analyzed through an ELISA-based technique and quantitative methylation-specific PCR. RESULTS Global DNA Methylation Index (p = 0.02) and promoter methylation of SSBP2 (p = 0.01...
BACKGROUND Coronary heart disease (CHD) is the leading cause of mortality worldwide. CHD clusters in families but this familial aggregation remains largely unexplained. ESR1 is a candidate gene for CHD although recent meta-analyses of the rs2234693 variant reported inconsistent evidence for association with myocardial infarction (MI) in men. The objectives of this study were to perform a qualit...
OBJECTIVE To investigate whether polymorphisms in the estrogen receptor alpha (ESR1) and beta (ESR2) genes were a risk factor for open-angle glaucoma (OAG). METHODS Participants 55 years and older from the population-based Rotterdam Study underwent, at baseline and at follow-up, the same ophthalmic examination, including visual field screening and stereo optic disc photography. A diagnosis of...
uterine leiomyoma (ul) is the most common benign smooth muscle cell tumor with as yet unknown etiology and pathogenesis. this study was carried out to investigate the association of esr1-351 a>g, esr1 -397 t>c and cyp1a1 (ile462val) polymorphisms with ul in female patients of iranian origin. in this case-control study, 276 patients with ul and 156 healthy women were recruited. the genetic polym...
BACKGROUND The measurement of ESR1 and PIK3CA mutations in plasma cell-free DNA (cfDNA) has been studied as a non-invasive method to quickly assess and monitor endocrine therapy (ET) resistant metastatic breast cancer (MBC) patients. METHODS The subjects of this retrospective study were a total of 185 plasma samples from 86 estrogen receptor-positive BC patients, of which 151 plasma samples w...
Uterine leiomyoma (UL) is the most common benign smooth muscle cell tumor with as yet unknown etiology and pathogenesis. This study was carried out to investigate the association of ESR1-351 A>G, ESR1 -397 T>C and CYP1A1 (Ile462Val) polymorphisms with UL in female patients of Iranian origin. In this case-control study, 276 patients with UL and 156 healthy women were recruited. The genetic polym...
BACKGROUND Despite evidence of estrogen's mood-enhancing effects, the association between estrogen receptor (ER) gene variants and lifetime major depression has been insufficiently studied. METHODS 3987 community-dwelling women aged 65years and over were recruited in France as part of the Three City Study. Current and past major depressive disorders (MDD) were diagnosed using the Mini-Interna...
The vitellogenin receptor (Vtgr) plays an important role in fish reproduction. This receptor functions to incorporate vitellogenin (Vtg), a macromolecule synthesized and released from the liver in the bloodstream, into oocytes where it is processed into yolk. Although studies have focused on the functional role of Vtgr in fish, the mechanistic control of this gene is still unexplored. Here we r...
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