Siglecs (sialic acid-binding Ig-like lectins) are mainly expressed in the immune system. Sn (sialoadhesin) (siglec-1), CD22 (siglec-2) and siglec-15 are well conserved, whereas the CD33-related siglecs are undergoing rapid evolution, as reflected in large differences in repertoires among the different mammals studied so far. In the present paper, we review recent findings on the signalling prop...

The PRINTS database houses a collection of protein fingerprints, which may be used to assign family and functional attributes to uncharacterised sequences, such as those currently emanating from the various genome-sequencing projects. The April 2002 release includes 1,700 family fingerprints, encoding approximately 10,500 motifs, covering a range of globular and membrane proteins, modular polyp...

Noonan syndrome is a multiple congenital anomaly syndrome, inherited in an autosomal dominant pattern. We studied 31 patients (18 males and 13 females) affected by this disorder regarding their clinical and genetic characteristics. The most frequent clinical findings were short stature (71%); craniofacial dysmorphisms, especially hypertelorism, ptosis, downslanting of the palpebral fissures; sh...

Biomedical research uses gene expression in order to understand biological processes and diseases. The level of gene expression is subject to change during the lifetime of an individual and this deregulation can reflect ageing-associated disorders and decline in physical ability. By studying the genome-wide expression trends of the human genes, underlying age-associated molecular processes may ...

High Impedance Fault (HIF) detection is increasingly a concern of distribution network protection engineers. Practical methods to deal with HIFs are in great demand in the USA, where HIFs are not detected by conventional protection devices. The lack of a globally accepted description of HIFs is a difficulty for HIF detection. In the effort to understand and explain HIFs, we have carried out a t...

It is essential to understand the consumption pattern of food and how it changes over time to formulate sound economic policies as well as marketing and pricing strategies. In this study, we estimate the Quadratic Almost Ideal Demand System with six rounds of the Family Income Expenditure Survey exploiting the conditional linearity of the demand system. We find that the Filipino diet has become...

ABSTRACT The main objective of this study is to empirically test capital structure decisions in Portuguese family-owned businesses under trade-off theory (TOT) and pecking order (POT) attend the relationships between family/business interaction agency conflicts. Family-owned are essential for development economies, but financing logic they adopt not yet adequately clarified by scientific resear...

Driven by economic development, ideational changes and family planning policies, the Chinese has experienced significant change over past several decades. Based on data from 2018 wave of China Family Panel Studies, this study analyzes China’s younger generations’ union formation childbearing behaviors. The results show that although average age entry into a first marriage continues to rise, you...