OBJECTIVE The purpose of this study was to evaluate the changes in esophageal physiology that are produced after laparoscopic surgery in patients with gastroesophageal reflux disease (GERD). METHODS From May 1996 until January 2000, 13 patients with GERD underwent antireflux laparoscopic surgery. In 8 patients, preoperative manometric studies showed motility disorders characterized by a decre...

c 2017 The Korean Society of Neurogastroenterology and Motility J Neurogastroenterol Motil, Vol. 23 No. 4 October, 2017 www.jnmjournal.org Stress exacerbates heartburn symptoms in gastroesophageal reflux disease (GERD) patients and also affects visceral sensitivity. The mechanism of visceral hypersensitivity in functional gastrointestinal disorders and functional heartburn remains unclear. Howe...

Background: Type 1 vanilloid receptors (TRPV1) have been described on esophageal afferent sensitive neurons. Stimulation of TRPV1 receptors with capsaicin may induce heartburn. Capsaicin is the pungent component of chili and the most extensively studied TRPV1 agonist. Objectives: To investigate the effect of esophageal stimulation with intraesophageal capsaicin administration on induction of es...

introduction: gastro-esophageal reflux (ger) is common among children of different ages and treatment is necessary since it could turn in to gastroesophageal reflux disease (gerd) and cause complications. in patients that do not respond to medical treatment and patients that have complications such as repeated apnea, pneumonia, stricture caused by esophagitis and failure to thrive, surgical tre...

BACKGROUND/AIMS Gastroesophageal reflux disease (GERD) is diagnosed based on symptoms of heartburn and regurgitation but is a heterogeneous condition which can be subclassified according to endoscopy and esophageal reflux monitoring. The aim of this study was to identify differences in demographic characteristics and reflux symptom patterns among patients with various spectrum of GERD. METHOD...

The purpose of this study was to determine the relation between posturally increased intra-abdominal pressure and lower/upper esophageal sphincter pressure changes in patients with gastroesophageal reflux disease. We used high resolution manometry to measure pressure changes in lower and upper esophageal sphincter during bilateral leg rise. We also examined whether the rate of lower and upper e...

OBJECTIVES The gastroenterology literature suggests that gastroesophageal reflux disease (GERD) is often associated with obesity. The National Institutes of Health uses body mass index (BMI) to identify patients who are overweight (BMI 25-30) or obese (BMI > 30). The aim of this study was to determine whether there is a relationship between laryngopharyngeal reflux (LPR) and elevated BMI. STU...

VV Gastroesophageal reflux disease (GERD) results from the failure of the lower esophageal sphincter to keep acid and other fluids in the stomach. This incompetency is commonly caused by the presence of a hiatal hernia, although a person can have pathologic reflux without a hiatal hernia and, conversely, can have no pathologic reflux even in the presence of a hiatal hernia. Most reflux is actua...

BACKGROUND/AIMS Transient lower esophageal sphincter relaxation (TLESR) is the main mechanism of gastroesophageal reflux disease (GERD). The aim of this study was to investigate the characteristics of transient lower esophageal sphincter movement in patients with or without gastroesophageal reflux by high-resolution manometry (HRM). METHODS From June 2010 to July 2010, we enrolled 9 patients ...

The prevalence of gastrointestinal reflux disease and reflux-related complications continue to rise, treatment options are limited. Medical management alone is often ineffective chronic use carries inherent risk. Magnetic sphincter augmentation represents a reasonable viable option for appropriately selected patients. Compared surgical wraps, magnetic (MSA) may provide similar rates patient sat...