We aimed to determine whether the newborn lamb at term is a valid model for studying gastroesophageal reflux. Seven bottle-fed lambs, ages 2 to 3 days, underwent esophageal multichannel intraluminal impedance-pH monitoring (MII-pH). A total of 196 reflux episodes were recorded, including 73% alkaline and 27% weakly acidic. No acid refluxes were observed. Median bolus clearance time was 4  secon...

Anecdotal reports suggest that obstructive sleep apnea syndrome (OSAS) patients may suffer from frequent nocturnal gastroesophageal reflux (GER) and that nasal continuous positive airway pressure may be an effective form of antireflux therapy in this population. To confirm these clinical impressions, we performed two consecutive days of 24-h esophageal pH monitoring, nocturnal esophageal pressu...

BACKGROUND High-resolution manometry (HRM) is a breakthrough in the morphological study of the gastroesophageal junction (GEJ) and its degrees of disruption. OBJECTIVES a) Assessment of risk factors involved in the disruption of the GEJ in patients with gastroesophageal reflux (GER) symptoms; b) the relationship between the type of GEJ and GER demonstrated by 24 hours pH-monitoring; and c) id...

Malfunction of the lower esophageal sphincter results in acid reflux into the esophagus. Reflux is mostly episodic so that the esophagus is not often presented with a continuous acid load. Prediction of esophageal disease related to reflux takes into account the pH of the refluxate and the duration of reflux. Expulsion of the refluxate back into the stomach shortens the time of exposure. The vo...

Eosinophilic esophagitis (EE) and gastroesophageal reflux disease (GERD) have overlapping clinical, manometric, endoscopic and histopathologic features. The diagnosis of EE is nowadays based upon the presence of 15 or more eosinophils per high power field (eo/HPF) in esophageal biopsies. We report the cases of two young males suffering from dysphagia and recurrent food impaction with reflux eso...

HYPOTHESIS Infants with rotational abnormalities of the midgut mesentery are at high risk for gastroesophageal reflux disease (GERD) and for sudden infant death (SID) from GERD. DESIGN A survey of the prevalence of GERD and the risk factor for SID from GERD in a case series of infants treated for congenital anomalies that include intestinal malrotation. Eighty-one (89%) of the infants studied...

The ability to reproduce chest pain and to identify the esophagus as the source of this pain are the major reasons why provocation testing has become standard in the evaluation of patients with noncardiac chest pain. Recent studies that challenge the validity of performing provocation tests have polarized experts into two camps: those who would abandon such testing because of its low sensitivit...

BACKGROUND There is a large consensus to preserve the distance of 5 cm above the proximal border of the lower esophageal sphincter (PBLES) as appropriate to the location of the electrode of the pH-metry. The main objective of this study is to determine whether placement of the electrode below the recommended location achieves a significant difference in the calculation of the DeMeester score. ...

TO THE EDITOR: We read with interest the study by Penagini et al, who investigated 50 refractory patients with a diagnosis of functional heartburn (FH) according to Rome III criteria in the first 24 hours of wireless pH monitoring. They described that 15/50 patients had a pathological acid exposure time (AET) after the first day of monitoring, which changed their diagnosis from FH to non-erosiv...

Corresponding author: Chang Won Lee http://orcid.org/0000-0002-6184-7171 Department of Internal Medicine, Busan St. Mary’s Hospital, 25-14, Yonghoro 232beon-gil, Nam-gu, Busan 48575, Korea E-mail: [email protected] We thank Dr. Yi for his comments in response to our study, “Prevalence and risk factors of gastroesophageal reflux disease in patients with type 2 diabetes mellitus” [1]. Prevalence...