introduction: as one of the most common cancers among head and neck malignancies, cancer of the oral cavity probably has some variations in countries with a high prevalence of esophageal cancer.  materials and methods: patients with oral cavity cancer who were treated at two tertiary referral centers from january 1999 to january 2009 were included in this study. in addition to demographic data,...

Esophageal cancer is one of the most fatal diseases worldwide mainly because of its rapid progression and poor prognosis. Although the incidence of esophageal adenocarcinoma has markedly risen in North America and Europe in the past several decades, esophageal squamous cell carcinoma is still the predominant subtype of esophageal cancer, especially in China. It accounts for more than 90% of all...

BACKGROUND The molecular backgrounds that determine therapeutic effectiveness in esophageal cancer remain largely unknown. Breast cancer susceptibility gene 1 (BRCA1) expression has been found to switch the response to cisplatin- or paclitaxel-based chemotherapy. It remains unclear how variations in BRCA1 expression influence clinical outcomes in esophageal cancer. PATIENTS AND METHODS Quanti...

AIM To investigate the role of Golgi phosphoprotein 3 (GOLPH3) in tumour growth and metastasis of esophageal squamous cancer. METHODS A lentiviral shRNA-vector was utilized to stably knockdown GOLPH3 in Eca-109 esophageal squamous cancer cells. mRNA transcription and protein expression of GOLPH3 were examined by real-time quantitative PCR and Western blotting, respectively. Cell proliferation...

background: chronic myeloid leukemia is a common cancer in human and chemical therapy is a routine method for treatment that has some side effects. so the goal of this study was the use of natural compound such as cell wall obtained from saccharomyces cerevisiae ( s. cerevisiae ) and saccharomyces boulardi ( s. boulardi ) and iron nanoparticles on the growth inhibition of k562 cell line. method...

introduction: esophageal and gastric cancers are among the most common cancers in iran. usually survival of these cases is poor despite of treatment. here we studied outcome of these cases in our center to have an estimation of general prognosis of patients. methods: in this retrospective study, we reviewed the data of patient's files before treatment, including cancer stage at diagnosis, types...

esophageal cancer is the second most common malignancy in iranian men; it is the third in women. it is killing about 5800 iranians each year. squamous cell carcinoma (scc) is presently the most common type of esophageal cancer accounting for about 90% of all esophageal cancers in iran. recent studies in iran have shown that there is a gradual increase in the incidence of adenocarcinoma of the d...

It is well established that loss of a growth inhibitory response to transforming growth factor-B (TGF-B) is a common feature of epithelial cancers including esophageal cancer. However, the molecular basis for the abrogation of this key homeostatic mechanism is poorly understood. In esophageal cancer cell lines that are resistant to TGF-B–induced growth inhibition, TGF-B also fails to decrease t...

background cancer stem cells play crucial roles in resistance to therapeutic schemes and relapse of disease, so it is important to find targeted therapies that kill them selectively. breast cancer is the most common cancer in females living in all part of the world including iran and it has an important burden in public health with direct impact on patients’ families. breast cancer in young adu...