AIMS The aim was to provide comprehensive information on the use of cardiac implantable electronic device (CIED) and catheter ablation therapy in the European Society of Cardiology (ESC) area. METHODS AND RESULTS The European Heart Rhythm Association (EHRA) has collected data on use of invasive arrhythmia managements since 2008. Fifty-one of the 56 ESC member countries provided data for the E...

OBJECTIVE To examine the performances of an alternative strategy to decide initiating BP-lowering drugs called Proportional Benefit (PB). It selects candidates addressing the inequity induced by the high-risk approach since it distributes the gains proportionally to the burden of disease by genders and ages. STUDY DESIGN AND SETTING Mild hypertensives from a Realistic Virtual Population by ge...

Mouse embryonic stem cells (ESC) make cell fate decisions based on intrinsic and extrinsic factors. The decision of ESC to differentiate to multiple lineages in vitro occurs during the formation of embryoid bodies (EB) and is influenced by cell-environment interactions. However, molecular mechanisms underlying cell-environmental modulation of ESC fate decisions are incompletely understood. Sinc...

OBJECTIVES To investigate the prevalence of extended-spectrum cephalosporinase (ESC)-producing Escherichia coli in pigs at slaughter and retail meat, and possible associations with the consumption of third- and fourth-generation cephalosporins. METHODS During 2009, faecal samples from Danish pigs (n=786) were collected at slaughter, and 866 meat samples [Danish: pork (153), broiler meat (121)...

BACKGROUND We investigated whether differentiation of embryonic stem cells (ESCs) in ischemic myocardium enhances their immunogenicity, thereby increasing their chance for rejection. METHODS AND RESULTS In one series, 129/SvJ-derived mouse ESCs (ES-D3 line) were transplanted by direct myocardial injection (1 x 10(6) cells) into murine hearts of both allogeneic (BALB/c, n=20) and syngeneic (12...

Environmental sound classification (ESC) is a challenging problem due to the complexity of sounds. The performance heavily dependent on effectiveness representative features extracted from environmental However, ESC often suffers semantically irrelevant frames and silent frames. In order deal with this, we employ frame-level attention model focus relevant salient Specifically, first propose con...

background: mesenchymal stem cells (mscs) are important candidates for msc-based cellular therapy. current paradigm states that mscs support local progenitor cells in damaged tissue through paracrine signaling. therefore, study of paracrine effects and secretome of mscs could lead to the appreciation of mechanisms and molecules associated with the therapeutic effects of these cells. this study ...

background: the present study was designed to evaluate the homing potential of mouse embryonic stem cells (esc) treated with erythropoietin (epo) in hematopoietic organs such as spleen and liver after transplantation using morphological and immuno-histochemical techniques. methods: day-four embryoid body (eb)-derived cells were dissociated and re-plated in medium in the presence and absence of ...

OBJECTIVE To obtain a pure population of smooth muscle cells (SMC) derived from mouse embryonic stem cells (ESC) and further assess their functions. METHODS A vector, expressing both puromycin resistance gene (puro(r) ) and enhanced green fluorescent protein (EGFP) gene driven by smooth muscle 22α (SM22α) promoter, named pSM22α-puro(r)-IRES2-EGFP was constructed and used to transfect ESC. Tra...

While traditional perturbation-based extremum seeking controllers (ESC) for vapor compression systems have proven effective at optimizing power without requiring a process model, the algorithm’s requirement for multiple distinct timescales has limited the applicability of this method to laboratory tests where boundary conditions can be carefully controlled, or simulation studies with unrealisti...