The Enzyme Linked ImmunoSpot (ELISPOT) is a new rapid T cell based blood test (otherwise known as an interferon-c assay) for the diagnosis of latent tuberculosis infection. The commercially available form of the assay, T-SPOTH TB (Oxford Immunotec, Abingdon, UK) has European regulatory approval as an in vitro diagnostic test and is increasingly being used in clinical practice. The test is based...

The ‘‘Dose-Finding Study of the Novel Vaccine, MVA85A, in Healthy Bacille Calmette-Guérin [BCG]–Vaccinated Infants’’ by Scriba et al [1] in this issue of the Journal takes the development of this new vaccine candidate for tuberculosis a further step down its development pipeline. There are many new tuberculosis vaccines at different stages of development [2], but this vaccine is the first to be...