About 8% of the human genome is made up of endogenous retroviruses (ERVs). Though most human endogenous retroviruses (HERVs) are thought to be irrelevant to our biology notable exceptions include members of the HERV-H family that are necessary for the correct functioning of stem cells. ERVs are commonly found in two forms, the full-length proviral form, and the more numerous solo-LTR form, thou...

Bats are increasingly recognized as reservoir species for a variety of zoonotic viruses that pose severe threats to human health. While many RNA viruses have been identified in bats, little is known about bat retroviruses. Endogenous retroviruses (ERVs) represent genomic fossils of past retroviral infections and, thus, can inform us on the diversity and history of retroviruses that have infecte...

BACKGROUND Obesity may cause adverse effects on the respiratory system. The main purpose of this study was to investigate how various measures of obesity are related to arterial blood gases and pulmonary function. METHODS This is a cross-sectional study of consecutive morbidly obese patients with normal lung function. Blood gas samples were taken from the radial artery after 5 min of rest wit...

The Ethiopian Rift Valley (ERV) is characterized by arid and semi-arid climate with groundwater as the most important water resource used for drinking irrigation purposes. However, in region, people are suffering from severe scarcity exacerbated effect. Besides availability, endemic quality issues critical affect suitability of human health risks. present study evaluates agricultural purposes Z...

Slow spirometry and forced spirometry (flow volume loop) are often used to measure clinically relevant lung volumes and forced expiratory and inspiratory flows. Dynamic parameters, such as forced expiratory volumes in one second (FEV1) or forced vital capacity (FVC) and static lung volumes, such as expiratory reserve volume (ERV), inspiratory capacity (IC) and inspiratory vital capacity (IVC) c...

Indoor air quality and health are major areas of concern in northern remote communities where homes experience varying occupancy, often overcrowding influenced by ventilation. Heat/energy recovery ventilators installed the north selected to provide required minimum ventilation rate set standards (ASHRAE 62.2, etc.). Northern overcrowded become under-ventilated, leading deteriorated IAQ, mold he...

Abstract The immunosuppressive tumor microenvironment in ovarian cancer (OC) enables these tumors to evade the immune system, resulting late diagnosis and poor therapeutic outcomes for patients. This immunosuppression can be partially reversed with epigenetic inhibitors, which stimulate an immunogenic interferon response OC cells by inducing transcription of repetitive elements (REs). However, ...

Abstract Hypomethylating agents (HMA) have become the backbone of nonintensive acute myeloid leukemia/myelodysplastic syndrome (AML/MDS) treatment, also by virtue their activity in patients with adverse genetics, for example, monosomal karyotypes, often losses on chromosome 7, 5, or 17. No comparable is observed cytarabine, a cytidine analogue without DNA-hypomethylating properties. As evidence...

REASONS FOR PERFORMING STUDY Equine rhinitis viruses (ERV) cause respiratory disease and loss of performance in horses. It has been suggested that the economic significance of these viruses may have been underestimated due to insensitive methods of detection. OBJECTIVES To develop a sensitive, rapid, real-time RT-PCR (rRT-PCR) assay suitable for the routine diagnosis and epidemiological surve...