نتایج جستجو برای: er probe
تعداد نتایج: 147915 فیلتر نتایج به سال:
Human breast tumors that are initially responsive to tamoxifen (TAM) eventually relapse during treatment. Estrogen receptor (ER) expression and function are often preserved in these tumors, and clinical evidence suggests that this relapse may be related to TAM's known agonistic properties. ER can interact with the activator protein-1 (AP-1) transcription factor complex through protein-protein i...
Norbormide (NRB) is a unique compound that acts directly on rat vascular myocytes to trigger a contractile process, through an as yet unknown mechanism, which results in the selective contraction of rat peripheral arteries. To gain insight into the mechanisms involved in NRB rat-selective activity, we investigated the subcellular distribution of NRB-AF12, a nitrobenzoxadiazole (NBD)-derivative ...
Quantum thermometry exploits the high level of control in coherent devices to offer enhanced precision for temperature estimation. This highlights need constructing concrete estimation strategies. Of particular importance is collisional thermometry, where a series ancillae are sent sequentially probe system's temperature. In this paper we put forth complete framework analyzing using Bayesian in...
Estrogen receptors alpha (ERalpha) and beta (ERbeta) have distinct functions and differential expression in certain tissues. These differences have stimulated the search for subtype-selective ligands. Therapeutically, such ligands offer the potential to target specific tissues or pathways regulated by one receptor subtype without affecting the other. As reagents, they can be utilized to probe t...
This paper aims at reviewing the current advancements of high pressure experimental geosciences. The angle chosen is that of in situ measurements at the high pressure (P) and high temperature (T) conditions relevant of the deep Earth and planets, measurements that are often carried out at large facilities (X-ray synchrotrons and neutron sources). Rather than giving an exhaustive catalogue, four...
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Physical map reconstruction in the presence of er rors is a central problem in genetics of high compu tational complexity A parallel genetic algorithm for a maximum likelihood estimation based approach to physical map reconstruction is presented The estima tion procedure entails gradient descent search for de termining the optimal spacings between probes for a given probe ordering The optimal p...
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