Rodents have robust wound healing mechanism compared to other animal species. The major mechanisms of wound healing differ between rodents and humans. In humans, wound healing primarily depends on re-epithelialization and granulation tissue (GT) formation, whereas wound contraction is more important during rodent wound closure. In this study, we described a novel excisional wound-splinting mode...

PURPOSE To evaluate the clinical efficacy of morselized amniotic membrane and umbilical cord tissue (MAU) in treating refractory corneal epithelial defect in ocular cicatricial diseases. METHODS Retrospective review of four patients with ocular cicatricial diseases treated with topical MAU for corneal epithelial defects refractory to conventional treatments including topical lubricants, autol...

Silymarin, an extract from Silybum marianum, has been shown to have antioxidant properties. However, there is no scientific report on wound healing activity of the silymarin. The purpose of this study was to evaluate the effect of topical administration of silymarin on excision wound healing in rats. Excision wounds were made on the back of rats. Rats were divided into three groups, as control,...

The present manuscript was mainly focused to evaluate the multiherbal formulation PACT (containing extracts of Pongamia pinnata Linn., Artocarpus lakoocha, Cynodon dactylon Pers. and Tridax procumbens Linn.) for wound healing potential employing two common wound models i.e. excision wound and incision wound models. The wound contraction area and epithelialization period was measured in excision...

In mammals, uterine epithelium is remodeled cyclically throughout adult life for pregnancy. Despite the expression of CD9 in the uterine epithelium, its role in maternal reproduction is unclear. Here, we addressed this issue by examining uterine secretions collected from patients undergoing fertility treatment and fertilization-competent Cd9(-/-) mice expressing CD9-GFP in their eggs (Cd9(-/-)T...

Abstract The atopic environment diminishes wound re-epithelialization and the defect in healing process is IL-4 dependent. represses fibronectin secretion from keratinocytes impairs ability of culture to migrate into a scratch close vivo. Addition increased closure assay vitro tissue vivo when was applied topically. In this study, human skin/mouse xenografting model used test impair skin whethe...

Endoscopic argon plasma coagulation and bipolar electrocautery are currently preferred treatments for chronic radiation proctitis, but ulcerations and strictures frequently occur. Radiofrequency ablation (RFA) has been successful for mucosal ablation in the esophagus. Here we report the efficacy of RFA with the BarRx Halo(90) system in three patients with bleeding from chronic radiation proctit...

BACKGROUND Lower T-junction wound dehiscence following breast reduction surgery or mastopexy constitutes a vexing and grievous complication both to the surgeon and the patient. Treatment modalities that can expedite wound healing and reepithelialization rates are highly craved. The objective of this study was to assess wound healing and epithelialization rates of open wounds following breast re...

Aged skin heals wounds poorly, increasing susceptibility to infections. Restoring homeostasis after wounding requires the coordinated actions of epidermal and immune cells. Here we find that both intrinsic defects and communication with immune cells are impaired in aged keratinocytes, diminishing their efficiency in restoring the skin barrier after wounding. At the wound-edge, aged keratinocyte...

Re-epithelialization and wound healing effect of aqueous extract of Tetrapleura tetraptera on extensive full thickness skin wound was studied in rabbits. The extract of Tetrapleura tetraptera was used in dressing cutaneous wounds. On day two, fibrin and fibronectin cross-linked together and formed a plug which trapped proteins and prevented further blood loss. Dressing of wound commenced on the...