The early prediction of intractability is a major challenge in epileptology. Some prognostic factors have been pointed out, most of which simply underlined that partial epilepsy is more difficult to control than idiopathic generalized epilepsy (IGE). Indeed, the main predictors are the presence of a brain lesion demonstrated by neuroimaging or suggested by a neurological deficit or a developmen...

Drug-resistant epilepsies still remain one of the most profound problems of contemporary epileptology. Several mechanisms of drug resistance are possible; among them, genetic factors have a prominent place. Much importance is attached to genes, which encode enzymes that metabolize antiepileptic drugs CYP 3A, which belong to the family of cytochromes P450 and the genome of multidrug resistance, ...

The early prediction of intractability is a major challenge in epileptology. Some prognostic factors have been pointed out, most of which simply underlined that partial epilepsy is more difficult to control than idiopathic generalized epilepsy (IGE). Indeed, the main predictors are the presence of a brain lesion demonstrated by neuroimaging or suggested by a neurological deficit or a developmen...

Medicine prescriptions play an important role in medical treatments. More insight in medicine prescription behavior can lead to more efficient and effective treatments, as well as reflection on prescription behavior for specific physicians, types of medicines, or classes of patients. Most current medical visualization systems show health data only from the perspective of patients, whereas to un...

OBJECTIVE To review data on the causes, clinical features, and management of patients with epilepsy in Hong Kong. DATA SOURCES MEDLINE and Chinese Current Medical Contents were used to search the literature. A manual search of the Hong Kong Medical Journal, Hong Kong Practitioner, and Chinese Medical Journal (1982-2002) was also undertaken. STUDY SELECTION Key words for the literature searc...

Homocystein (Hcy) is regarded as a neuroexcitatory substance, which is therefore used as an epileptogenic agent in experimental epileptology. Experiments "in vivo" as well as "in vitro" revealed its relation to NMDA glutamate receptors, and its potential neurotoxicity. From the clinical aspect, hyperhomocysteinemia (HHcy), mostly as a marker of the risk factor in the vascular damage, was often ...

Many people with epilepsy remain drug-resistant, despite continuous efforts and advances in research treatment. It is mandatory to understand the epilepsy’s underlying etiology, whether it structural, genetic, infectious, metabolic, immune or (currently) unknown, as contains major information about clinical phenotype, cognitive comorbidities, (new) drug targets also help predict postsurgical ou...

In our study, we evaluated 249 patients with refractory seizures using video-EEG monitoring. In this sample, we identified 56 (22.5%) patients with psychogenic non-epileptic seizures – PNES only. Spontaneous seizures were recorded in 49 (87%) patients with PNES. Suggestive seizure induction using intravenous saline placebo was successful in 77.1% of induced PNES cases. Disease duration prior to...

Inhibition mediated by GABA-B receptors can play a role in epilepsy. We therefore studied its involvement in cortical epileptic afterdischarges in adult rats by means of a GABA-B receptor agonist baclofen. Three different experiments were performed with cortical epileptic afterdischarges and an additional experiment studied possible effect of baclofen on cortical interhemispheric (transcallosal...

Abstract Background Lacosamide (LCM) is a third-generation anti-seizure medication (ASM) approved for focal onset epilepsy in patients aged ≥4 years. Previous studies have reported an efficacy of LCM as add-on treatment brain tumour-related (BTRE). To date, there are no the literature focusing on lacosamide used monotherapy to treat BTRE. In our retrospective study we investigated and tolerabil...