Epileptic encephalopathy syndromes are disorders in which the epileptiform abnormalities are thought to contribute to a progressive cerebral dysfunction. Characteristic electroencephalogram findings have an important diagnostic value in classification of epileptic encephalopathy syndromes. In this paper, we focus on electroencephalogram findings of childhood epileptic encephalopathy syndromes a...

Epilepsy is one of the most common neurological disorders and affects almost 60 million people worldwide; many techniques were used to detect epileptic seizures in the EEG recording. In this study we have implemented the new non linear epileptic seizure detection, proposed by H.Ocak, the method is based on discrete wavelet analyse and Approximate Entropy. The detection technique is divided on f...

The analysis of epileptic discharges in magnetoencephalography with minimum norm estimates (MNE) is expected to provide more precise localization of epileptic discharges compared with electroencephalographic estimations. However, the clinical feasibility of MNE remains unclear. In this study, we aimed to elucidate the onset and propagation patterns of interictal spikes using MNE. Seven patients...

We apply a novel gene expression network analysis to a cohort of 182 recently reported candidate Epileptic Encephalopathy genes to identify those most likely to be true Epileptic Encephalopathy genes. These candidate genes were identified as having single variants of likely pathogenic significance discovered in a large-scale massively parallel sequencing study. Candidate Epileptic Encephalopath...

This study aimed to investigate the clinical characteristics and the treatment principles and methods of recurrent epileptic seizures in patients with neurological disorders. A retrospective analysis was performed of the clinical data, treatment methods and results in 13 patients with recurrent epileptic seizures attending the neurosurgery department. Of the 13 patients, 10 had a history of epi...

OBJECTIVE The paper aims to study the prevalence of depression in epileptic children and adolescents by reviewing the existing literature, looking for any association between depression in these children and their demographic or seizure related factors to highlight the potential risk factors for depression in epileptic children. METHODS A search of MEDLINE, NLM Gateway, Ovid and EMBASE was ca...

Thirty-one children divided into 3 groups were studied. Group I included 13 neurologically free children, aged 3-9 years and not receiving any medications. Group II consisted of 7 recently diagnosed non medicated epileptic children, aged 3.5-8 years. Eleven medicated epileptic children; aged 4-9 years represented group III. All children were examined thoroughly. EEG and brain CT scan were done ...

The epileptic seizure occurs at random by impaired brain functions. An epileptic seizure can be characterized in terms of paroxysmal occurrences of synchronous oscillations. In this paper, we suggest several approaches to evaluate the hidden characteristic of the data which can form the basis for diagnosis and prediction of epileptic seizures. These methodologies are applied on electroencephalo...

Epilepsy is a neurological disorder characterized by interruption of normal neuronal functions that is manifested by behavioral disorders, changing of awareness level, and presence of some sensory, autonomic and motor symptoms or signs. It is resulted from many different causes. Many antiepileptic drugs (AEDs) are considered to manage epileptic attacks. Some of them change metabolism and absorp...

Epileptic negative myoclonus is an uncommon seizure type characterized by a sudden, brief loss of muscle tone that may lead to falling. It has been associated largely with benign childhood epilepsy with centrotemporal spikes (rolandic epilepsy), although it may also be a feature of other epileptic syndromes. In patients with rolandic epilepsy, epileptic negative myoclonus usually appears during...