Epilepsy often occurs in comorbidity with mental diseases and disorders. Early detection and/or treatment of such disorders in patients affected by epilepsy, as well as their socialisation are crucially important since epileptic patients tend to suffer more due to lack of social support than to frequent epileptic seizures. Prevalence of psychiatric disorders is higher in patients with epilepsy ...

PURPOSE OF REVIEW This article reviews the most significant advances in the field of epilepsy associated with tuberous sclerosis complex, with emphasis on new advances in the knowledge of the pathophysiological mechanisms of epileptogenicity, progress in identifying the epileptogenic zone, and the rationale for surgical management in individuals with intractable seizures. RECENT FINDINGS Adva...

OBJECTIVE The interaction between epilepsy and sleep is known. It has been shown that patients with epilepsy have more sleep problems than the general population. However, there is no recent study that compares the frequency of sleep disorders in groups with medically refractory temporal lobe epilepsy (TLE) and extratemporal lobe epilepsy (ETLE). The main purpose of this study was to investigat...

objective:   intractable epilepsy is a serious neurologic problem with different etiologies. decreased levels of pyridoxal phosphate in central spinal fluid level of patients with intractable epilepsy due to pyridoxine dependency epilepsy were reported. the aim of this study was to compare plasma pyridoxal 5´-phosphate level in patients with intractable and controlled epilepsy. materials   &   ...

BACKGROUND Epilepsy is a neurological disorder characterized by epileptic seizures as a result of excessive neuronal activity in the brain. Approximately 65 million people worldwide suffer from epilepsy; 20-40% of them are refractory to medication therapy. Early detection of disease is crucial in the management of patients with epilepsy. Correct localization of the ictal onset zone is associate...

Temporal lobe epilepsy is the most important cause of medically intractable seizures. Complex partial seizures, the main clinical manifestation of temporal lobe epilepsy, arise primarily from the mesial temporal structures, the amygdala, and the hippocampus [1 , 2) . This form of epilepsy is also the most readily treatable with surgery: in most series, recovery is reported in 60-85% of cases [3...

PURPOSE The transient, mainly generalized, together with brief changes in EEG baseline immediately after eye closure, is called 'eye closure sensitivity' (ECS) which was first reported by Robinson in 1930 and there have been limited number of studies investigating ECS and epilepsy syndromes. Therefore, we aimed to reveal the possible relationship between ECS and the epilepsy syndromes in our ad...