Ethyl pyruvate (EP), a derivative of pyruvic acid, is known to have protective effects against ischemic cardiomyopathy and other disorders. However, little is known about its role in Adriamycin (ADR)-induced cardiomyopathy. The present study was designed to investigate the impact of EP on ADR-induced cardiomyopathy in an animal model. Sixty male Sprague-Dawley (SD) rats were divided into four g...

Objective(s): The main objective of this study was to investigate the variations of β-endorphin (β-EP), vasoactive intestinal peptide (VIP), serotonin (5-HT) and norepinephrine (NE) of immune thrombocytopenia (ITP) mice as well as the regulatory mechanism of prednison. Materials and Methods: Sixty BALB/c mice were randomly divided into control group, model group and prednison intervention grou...

Background: Toll-like receptors (TLRs) play a crucial role in early host defense against invading pathogens. Recognition of some bacterial pathogen associated molecular patterns (PAMPs) is mediated by TLR2, 4 and 5 while TLR3 distinguishes double stranded RNA. Interactions between the immune system and female reproductive system have important consequences for fertility and reproductive health....

Fabrication and electrochemical characterization of a sensor for the determination of epinephrine (EP), uric acid (UA) and folic acid (FA) is described. The sensor  was prepared using carbon paste electrode (CPE) modified with 3,4-dihydroxybenzaldehyde-2,4-dinitrophenylhydrazone (DDP) and carbon nanotubes (CNTs), which makes the modified electrode highly sensitive for the electrochemical detect...

Pyruvate is an endogenous antioxidant substance. The aim of this study was to investigate the protective effects of ethyl pyruvate (EP) on retinal vascular injury in diabetic retinopathy. To investigate the protective effect of EP on vascular cell apoptosis and blood-retinal barrier (BRB) breakage, we have used intravitreally methylglyoxal-(MGO-) injected rat eyes. Apoptosis of the retinal vasc...

BACKGROUND This study evaluated the efficacy and safety of irinotecan/cisplatin (IP) and etoposide/cisplatin (EP) in extensive-stage small cell lung cancer (ES-SCLC) and the distribution of uridine diphosphate glucuronosyltransferase (UGT1A1). The relationship between UGT1A1 genotypes and patient outcomes was also assessed. METHOD Patients with untreated ES-SCLC were randomly assigned to rece...

RATIONALE This study aims to evaluate the diagnostic value of beta-endorphin (β-EP) and brain natriuretic peptid (BNP) plasma concentrations for the early diagnosis of acute left heart failure and atrial fibrillation. PATIENT CONCERNS A total of 45 patients were included. These patients comprised 23 male and 22 female patients,and 20 healthy subjects who underwent physical examinations in the...

An experiment was conducted to study the effect of Epinephrine (EP) and bromocriptine (BR) on productive traits of laying hens. Thirty White Leghorn hens, 50 weeks old, were divided into three equal treatments (with 10 hens for each treatment): control, physiological serum (0.5 mL/hen/week), EP (0.5 mL/hen/week) and BR (100 g/kg of body weight (BW); w/v in absolute alcohol). Hens were injected ...