Seven uveal melanomas were stained for gamma enolase by an immunoperoxidase PAP (peroxidase-antiperoxidase) technique, and biochemical assays were carried out on tissue homogenates. A correlation between the biochemical assay and the immunoperoxidase staining was demonstrated. Two tumours with the highest biochemical assays showed positive staining for the enzyme, and 2 tumours with the lowest ...

individual Plg-Rs to monocyte recruitment may change over time (enolase-1 early vs H2B later). These suggestions imply that different populations of Plg-Rs could be targeted to regulate inflammatory cell recruitment in a temporal or site-specific manner. The resurrection of enolase-1 as a Plg-R by the Wygrecka et al provides impetus for such comparative studies. Conflict-of-interest disclosure:...

Despite being crucial for energy generation in most forms of life, few if any microbial antibiotics specifically inhibit glycolysis. To develop a specific inhibitor of the glycolytic enzyme enolase 2 (ENO2) for the treatment of cancers with deletion of ENO1 (encoding enolase 1), we modeled the synthetic tool compound inhibitor phosphonoacetohydroxamate (PhAH) into the active site of human ENO2....

Enolase is a multifunctional enzyme primarily involved in catalyzing the conversion of 2phosphoglycerate to phosphoenolpyruvate during glycolysis and the reverse reaction during gluconeogenesis[1–4]. Though typically expressed in the cytosol, enolase has been shown to migrate to the cell surface upon inflammatory signal[3]. It then enhances antigen presentation for the invasion of host cells vi...

Enolase genes from land plants and apicomplexa (intracellular parasites, including the malarial parasite, Plasmodium) share two short insertions. This observation has led to the suggestion that the apicomplexan enolase is the product of a lateral transfer event involving the algal endosymbiont from which the apicomplexan plastid is derived. We have examined enolases from a wide variety of algae...