Antipyrine is a useful probe to evaluate variation of in vivo activities of oxidative hepatic drug-metabolizing enzymes. Here we describe an approach using (13)C labeling and NMR spectroscopy for the direct and simultaneous analysis of major metabolites of antipyrine in human urine. [C-Methyl-(13)C]antipyrine (500 mg) was dosed orally to human volunteers, and the post-dose urine was analyzed by...

Gate-controllable transmission of terahertz (THz) radiation makes graphene a promising material for making high-speed THz wave modulators. However, to date, graphene-based THz modulators have exhibited only small on/off ratios due to small THz absorption in single-layer graphene. Here we demonstrate a ∼50% amplitude modulation of THz waves with gated single-layer graphene by the use of extraord...

In this paper, we propose a speech enhancement method based on spectral magnitude estimation. We modify the noise estimation from the minimum statistics method and combine with a maximum a posterior (MAP) decomposition, using the Rice-conditional probability and a non-Gaussian statistic model of the speech. We derive two versions of magnitude decomposition and magnitude-phase decomposition and ...

We study the low-frequency polarization response of a surface-charged oblate spheroidal particle immersed in an electrolyte solution. Because the charged spheroid attracts counterions which form the electric double layer around the particle, using usual boundary conditions at the interface between the particle and electrolyte can be quite complicated and challenging. Hence, we generalize Fixman...

The results of a complete one-loop calculation for the fermionic decay width Γ(h 0 , H 0 , A 0 → f ¯ f) of the neutral MSSM Higgs bosons are presented and the dominant light Higgs decay channel h 0 → b ¯ b is discussed in detail. The enhancement of Γ(h 0 → b ¯ b) compared to the standard Higgs decay is shown for pseudoscalar masses M A ≤ 300 GeV, where the one-loop contributions in the MSSM and...

Article history: Available online 18 April 2014

Background A comprehensive congenital cardiac MRI exam with contrast enhancement typically consists of multiple scans to evaluate dynamic contrast enhancement (DCE) characteristics, physiological function, blood flow, and anatomical assessment. However, multiple sequences require skilled operators, prolong the exam, and lengthen anesthesia duration for uncooperative patients. Thus, we propose a...

Patterns of human kinship commonly involve preferential treatment of relatives based on lineal descent (lineages) rather than degree of genetic relatedness (kindreds), presenting a challenge for inclusive fitness theory. Here, we examine effects of lineage and kindred characteristics on reproductive success (RS) and number of grandchildren for 130 men and 124 women in a horticultural community ...

An experiment investigated the effects of amplitude ratio ~235 to 35 dB in 10-dB steps! and fundamental frequency difference ~0%, 3%, 6%, and 12%! on the identification of pairs of concurrent synthetic vowels. Vowels as weak as 225 dB relative to their competitor were easier to identify in the presence of a fundamental frequency difference (DF0). Vowels as weak as 235 dB were not. Identificatio...

New theoretical results from large-scale relativistic close coupling calculations reveal the precise effect of resonances in collisional excitation of x-ray lines of Ne-like Fe XVII. By employing the Breit-Pauli R-matrix method and an 89-level eigenfunction expansion, including up to n = 4 levels, significant resonance enhancement of the collision strengths of forbidden and intercombination tra...