Fluorescence-based endpoint detection of microarrays with 10,000 or more molecular targets is a most useful tool for high-throughput profiling of biomolecular interactions, including screening large molecular libraries for novel protein ligands. However, endpoint fluorescence data such as images of reacted microarrays contain little information on kinetic rate constants, and the reliability of ...

When automatic speech recognition (ASR) is applied to hands-free or other adverse acoustic environments, endpoint detection and energy normalization can be crucial to the entire system. In low signal-to-noise (SNR) situations,conventional approaches of endpointing and energy normalization often fail and ASR performances usually degrade dramatically. The goal of this paper is to find a fast, acc...

OBJECTIVE To analyze the reliability and accuracy of the screening for adverse events (AEs) conducted by nurses taking the assessment by medical residents as the reference. DESIGN A validation study of the screening phase of a previous retrospective cohort study based on the patient record review that estimated the incidence of AEs (base study). SETTING Three general teaching hospitals in t...