Somatostatin receptor subtype 4 (SST4) has been shown to mediate analgesic, antidepressant and anti-inflammatory functions without endocrine actions; therefore, it is proposed be a novel target for drug development. To overcome the species differences of SST4 expression function between humans mice, we generated an humanized mouse line serve as translational animal model preclinical research. A...

Chondromas originating from the sella turcica are rare, and the most common initial symptoms are headache and visual disturbance. We describe a case of sellar chondroma with endocrine impairment as an initial manifestation that completely resolved after surgery. A 40-year-old Japanese woman with amenorrhea and galactorrhea for the last 2 years was referred to our department of neurosurgery for ...

Arachnoid cysts (ACs), particularly suprasellar cysts, cause a wide spectrum of endocrine disorders. Herein, we report two patients diagnosed with an extensive AC in the middle cranial fossa while being investigated for etiologies of precocious puberty and short stature. One of them required surgery due to his pubertal disorders associated with compression effects of cyst. After surgery, his pu...

Longitudinal growth assessment is essential in child care. Short stature can be promptly recognized only with accurate measurements of growth and critical analysis of growth data. The objective of this study was to determine the pattern of short stature among patients referred to an endocrine pediatric clinic, King Khalid University Hospital (KKUH), Riyadh, Saudi Arabia and to ascertain the aet...

The objective of this study was to compare the cost-effectiveness of four management strategies for a patient with an incidentally discovered asymptomatic pituitary microadenoma. A decision analytic Markov model was used to determine the incremental cost-effectiveness of four clinical management strategies: 1) expectant management, 2) PRL screening, 3) an endocrine screening panel (PRL, insulin...

BACKGROUND/AIM There are close interactions among the developing oral cavity, pituitary gland, and central nervous system (CNS) in early embryonic life. In this study we aimed to screen endocrine abnormalities in patients with orofacial clefts in the neonatal period. MATERIALS AND METHODS Thirty-one patients with isolated orofacial median clefts wereincluded in the study. Pituitary, thyroid, ...

INTRODUCTION The combination of a pituitary prolactinoma and an aldosterone-producing adrenal adenoma is extremely rare. To the best of our knowledge, double endocrine tumors in association with heart-hand syndrome have not previously been reported. CASE PRESENTATION A 21-year-old Japanese woman presented with galactorrhea and decreased visual acuity. A large pituitary adenoma with an increas...

Neuroendocrine tumors (NET ́s) can be small and situated almost anywhere throughout the body. Our objective was to investigate if whole body (WB) positron emission tomography (PET) with C-5-hydroxytryptophan (5-HTP) can be used as a universal imaging technique for NET ́s and to compare this technique with established imaging methods. Forty two consecutive patients with evidence of NET and a detec...

Background In patients with early onset or drug resistant hypertension (HTN) exclusion of secondary causes with imaging and endocrine testing is recommended. Traditionally a combination of echocardiography, renal ultrasound and renal CT angiography are used to investigate patients. Magnetic resonance imaging (MRI) is the gold standard imaging modality for the quantification of cardiac volumes a...