endocrine diseases, known as a curable etiology for depression, are common among men living with hiv (mlwh); while depression impedes the adherence to treatment and the perceived quality of life. we evaluated the changes in the depressive symptoms after the medical treatment of the underlying endocrine diseases among iranian mlwh. since april 2013 to march 2014, a convenience sample of 296 mlwh...

Introduction: Fanconi anemia (FA) is a genetic condition with extreme cancer predisposition resulting from abnormalities in repair of DNA breakage and crosslinks. Children with FA develop bone marrow failure (BMF) that is treated with androgen or hematopoietic cell transplantation, and are at risk for developing acute myeloid leukemia. In adulthood, persons with FA commonly develop squamous cel...

The vertebrate endocrine pancreas has the crucial function of maintaining blood sugar homeostasis. This role is dependent upon the development and maintenance of pancreatic islets comprising appropriate ratios of hormone-producing cells. In all vertebrate models studied, an initial precursor population of Pdx1-expressing endoderm cells gives rise to separate endocrine and exocrine cell lineages...

Vascular endothelial growth factor (VEGF) is a secreted polypeptide with specific effects on endothelial cell growth and vascular permeability. While previous studies have focused on the expression of VEGF associated with angiogenesis in tumor and embryonal tissues, little is known about the role of VEGF in normal adult tissues. In the present study, a specific antibody was used to study the im...

Endocrine cell proliferation fluctuates dramatically in response to signals that communicate hormone demand. The genetic alterations that override these controls in endocrine tumors often are not associated with oncogenes common to other tumor types, suggesting that unique pathways govern endocrine proliferation. Within the pancreas, for example, activating mutations of the prototypical oncogen...

Evidence for a common endodermal stem cell has been derived from kinetic studies in mouse small intestine which indicate that the turnover characteristics of endocrine cells are similar to those of other cell lineages (columnar and goblet cells). We have used continuous tritiated thymidine labelling and peptide immunocytochemistry on resin embedded semithin sections, a combination of techniques...

In the last decade, stem cell therapy has emerged as a promising treatment modality in the treatment of autoimmune diseases. Stem cells are primitive undifferentiated cells capable of self-renewal and differentiation into to virtually any tissue or organ [1]. They demonstrate infinite regenerative capacity additionally to the ability relocate and differentiate where needed. There are three cate...

A 69-year-old female presented to our institution with epigastralgia and abdominal distension. Upper gastrointestinal series revealed a 5 cm ulcerative lesion with irregular margins and elevated distinct borders from the angle to the pyloric ring. Gastroendoscopy revealed a Borrmann type 2 tumor. Several biopsied specimens revealed proliferation of small and heterogeneous cancer cells with rich...

Hormone secretion by pituitary cells is decreased by roscovitine, an inhibitor of cyclin-dependent kinase 5 (Cdk5). Roscovitine treatment reorganizes cortical actin and ultrastructural analysis demonstrates that roscovitine limits the ability of secretory granules to approach the plasma membrane or one another. Trio, a multifunctional RhoGEF expressed in pituitary cells, interacts with peptidyl...

The production of insulin-producing β cells from human embryonic stem cells (hESCs) in vitro represents a promising strategy for a cell-based therapy for type 1 diabetes mellitus. To explore the cellular heterogeneity and temporal progression of endocrine progenitors and their progeny, we performed single-cell qPCR on more than 500 cells across several stages of in vitro differentiation of hESC...