A significant increase in cardiovascular medication use during pregnancy occurred in recent years. Only limited evidence on safety profiles is available, and little is known about the mechanisms of adverse effect on the fetus. We hypothesized that drug-induced bradycardia is the leading mechanism of developmental toxicity. Embryotoxicity was tested in ovo after administration of various doses o...

Therapy with the antiepileptic drug valproic acid (2-propylpentanoic acid, VPA) during early pregnancy can cause similar teratogenic effects (neural tube defects) in human and mice. In this study a new molecular bioassay is presented using following endpoints: differentiation of F9 teratocarcinoma cells, altered cell morphology, induction of possible targeted genes, and the induction of viral R...

Many industrial chemicals and their respective by-products need to be comprehensively evaluated for toxicity using reliable and efficient assays. In terms of teratogenicity evaluations, the murine-based embryonic stem cell test (EST) offers a promising solution to screen for multiple tissue endpoints. However, use of a mouse model in the EST can yield only a limited understanding of human devel...

The study of pharmacological studies the veterinary medicinal product for external use in form ointment – “Dibutalastin Ointment” is a mandatory stage preclinical research drug, which new development PP “Biopharm” and LLC “DEVIE”. In scientific experiment on laboratory animals, it possible to assess drug's safety different terms determine zone toxic action doses that do not cause harmful effect...

disodium glycyrrhetinic acid hemiphthalaic (gap) was evaluated for developmental toxicity in pregnant nmri mice. gap was administered intrapcritoneally on days s, 9, 10, of gestation at doses of 0, 25, 50 and 75 mg/kg/dav. on gestation day of is, after operational delivery, the fetuses were examined for soft tissue, external and skeletal defects. increased absorptions, dead fetuses, and reduce ...