The aim of this study was to describe lamivudine (3TC) pharmacokinetics (PK) in HIV-infected nonpregnant and pregnant women and their fetuses. Samples were collected according to therapeutic drug monitoring from 228 women treated with lamivudine and retrospectively analyzed by a population approach. The samples were also collected from cord blood and amniotic fluid at birth. Lamivudine pharmaco...

in rabbits, especially in some races, limb movement disorder called splay legs, are mostly unilateral or bilateral in front or hind legs at an early age. the severity ranges from mild to severe in this case. in breeding colony of albino dutch laboratory rabbits, the splay leg disorder has been observed over the years permanently.within the scope of this research, 1.5-2.5% of 700-750 number of c...

Motivated by applications to service systems, we develop simple engineering approximation formulas for the steady-state performance of heavily-loaded G/GI/n+GI multi-server queues, which can have non-Poisson and non-renewal arrivals and non-exponential service-time and patience-time distributions. The formulas are based on recently established Gaussian manyserver heavy-traffic limits, but invol...

abstract aims: chemical precipitation is a simple, efficient, and cost-effective method for eliminating heavy metals found in landfill leachate. the aim of the present study was to compare the efficacy rates of cadmium removal with the coagulants like poly aluminum chloride and lime using chemical precipitation method. materials & methods: in this experimental study, the raw studied samples wer...

The pharmacokinetics (PK) of continuous erythropoietin receptor activator (CERA), a PEGylated erythropoietin (EPO) derivative, was studied in sheep after bone marrow (BM) busulfan ablation by using a receptor-based recirculation model and tracer interaction method (TIM) experiments. The nontracer CERA component of the TIM was analyzed using a noncompartmental approach. In contrast to EPO elimin...

measles is a highly contagious disease. by the end of 2013, 84% of children had received at least a single dose of measles vaccine by their second birthday, and 148 countries had included a second dose as part of routine immunization. in 2002, the iranian ministry of health and medical education developed a comprehensive strategy to eliminate measles including mass immunization campaign for peo...

in this paper, we present a numerical algorithm for solving matrix equations $(a otimes b)x = f$  by extending the well-known gaussian elimination for $ax = b$. the proposed algorithm has a high computational efficiency. two numerical examples are provided to show the effectiveness of the proposed algorithm.

The key elimination step for the formation of 3-chloro- and 3-fluorobenzyne from 2-chloro-6-fluorophenyllithium displays a pronounced solvent-dependent regioselectivity. 6Li and 13C NMR spectroscopic studies on 2-chloro-6-fluorophenyllithium reveal a single monomeric aryllithium, suggested by DFT computational studies to be a trisolvate. Rate studies indicate that the elimination of LiCl and Li...

According to the recent reports of World Health Organization (WHO), 20 000 to 30 000 deaths occur annually due to Leishmaniasis and 200 000 to 400 000 new cases occur worldwide each year. India stands with maximum number of visceral leishmanial cases (20102013) and Bihar state alone reports more than 70% of the total reported cases in India. Efforts are being made by the Government of India in ...