MHC-congenic mice prefer to mate with mice of different MHC types and are able to discriminate between MHC-congenic mice by their urine odors, but nothing is known about behavioral differences among MHC-congenic mice. The present experiments examine the strain and sex differences in MHC-congenic C57BL/6J and B6-H-2K mice with respect to exploration and fear motivated behaviors in the elevated p...

The effects of kindling of the right anterior medial amygdala of Wistar rats was studied. Kindling lastingly increased anxiety (decreased open-arm exploration) in the elevated plus-maze 1 week after the last kindled seizure, replicating previous findings. Changes in anxiety were independent of changes in exploration or activity in either the plus-maze or hole board. A new finding is the depende...

Several lines of research on human and rodent subjects have demonstrated that early-life stress results in multiple negative outcomes, including increased incidence of psychopathologies. The current study sought to further the research on adolescent versus adult rats on anxiety-like reactions to chronic stress. The purpose of the current study was to assess whether 7 days of chronic restraint s...

The present study was aimed to screen neuroprotective effects of lantana camara in BPA induced-cognitive dysfunction and oxidative stress rats. In methodology animals were divided into 5 groups. Group I serve as vehicle control group administered with 2 ml normal saline. II 50 µg/kg for 21 days. III IV served drug treated pre 1 week methanolic extract L.camara (250 500 mg/kg bw/day orally). V s...

The phospholipid complex of the obtained aqueous fraction (AF) was prepared with Phospholipon 90H. The size of nanophytosomes was determined by dynamic light scattering. HPTLC fingerprinting of the AF was also performed. PTZ and ICES models were used to evaluate the anticonvulsant activity while Rotarod test, Elevated Plus maze test, and Forced swimming test were used to evaluate other neuropha...

Aim. To assess memory improvement and neuroprotective and antioxidant effects of Mitragyna inermis (M. inermis) leaf decoction on the central nervous system. Methodology. Leaf decoction of M. inermis was tested on learning and memory in normal and scopolamine-induced cognitive impairment in mice using memory behavioral tests such as the Morris water maze, object recognition task, and elevated p...

Ethnopharmacological relevance: Dysphania ambrosioides (L.) Mosyakin & Clemants (Chenopodiaceae) is a medicinal plant known for its anxiolytic, antidepressant and anticonvulsant activities in Cameroonian folk medicine. Aim of the study: The aim this work to evaluate anxiolytic effects aqueous extracts investigate mechanism action. Materials methods: Elevated plus maze test open field were u...

The effect of two supplements containing resveratrol (“Resveratrol” and “Enoant”) on the psycho-emotional state animals with an initial index anxiety depression above 0.5 was studied. For this, “Elevated plus maze” (EPM) “Forced swim test” (FST) were used. “Resveratrol” significantly reduces depressivity (ID) in males 7th 14th days application, females – only day. No significant influence (AI) ...

Methamphetamines (MA) are psychostimulant drugs that are known to change individuals' behavior. Psychostimulants could either evoke positive emotions (e.g. joy and happiness) or attenuate negative emotional states (e.g. anxiety and depression) in humans. In animal experiments, the test of elevated plus-maze (EPM) is widely used. This test is appropriate f...