In recently, many studies tried that fine medicinal plant that may be useful in treatment of psychological diseases. Coriandrum sativum (CS) overgrows in the different parts of Iran. In this study we investigated the effects of hydro-alcoholic extract of Coriandrum sativum on anxiety reaction in Mice. In this study, fourty male mice (25-30 gr) in elevated plus maze model were used. Different do...

Olive oil is the major component of the Mediterranean diet and has rich history of nutritional and medicinal uses. In the present study, the antidepressant and anxiolytic effects and their neurochemical basis following repeated administration of extravirgin olive oil were monitored. Male albino Wistar rats were used during study. Animals of test group were given olive oil orally at the dose of ...

The endocannabinoid system is involved in the control of many physiological functions, including the control of emotional states. In rodents, previous exposure to an open field increases the anxiety-like behavior in the elevated plus-maze. Anxiolytic-like effects of pharmacological compounds that increase endocannabinoid levels have been well documented. However, these effects are more evident ...

Previous studies indicated that Foeniculum vulgare (FV) as a folk remedy plant that overgrows in the different parts of Iran and suggested that have antinociceptive activity and sedative. In this study, we investigated of anxiolytic effects in different doses of the extracts of FV. In this study, fourty male mice (25-30 gr) were used in elevated plus maze model. Different doses of the extract o...

Portulaca oleracea (PO) overgrows in the different parts of Iran. In previous studies, ethanolic extracts of PO showed antinociceptive activity, sedative in animal. This study was designed to evaluate anxiolytic effects in different doses of the aqueous decoction extracts of PO. In this study, fourty male mice (25-30 g) were used in elevated plus maze model. Different doses of the extract. (25,...

Introduction: Effective perception of fear signals is crucial for organism survival. When threated, the organism indicates defensive behaviors. Methods: Elevated plus–maze has high efficiency for measurement of fear behavior and is widly used for fear behavior determination. Increase in two parameters percent of openarm entries (%OAE) and percent of time spent in the open-arm (%OAT) in the ...

Disrupted circadian rhythms are a core feature of mood and anxiety disorders. Circadian rhythms are coordinated by a light-entrainable master clock located in the suprachiasmatic nucleus. Animal models of mood and anxiety disorders often exhibit blunted rhythms in locomotor activity and clock gene expression. Interestingly, the changes in circadian rhythms correlate with mood-related behaviours...

Anxiety is associated with diverse range of psychiatric conditions. In the present study, antianxiety effect of fluoxetine, citalopram (SSRI's), gabapentin (antiepileptic drugs), venlafaxine (SNRI), clozapine and resperidone (atypical antipsychotics) and a herbal preparation ashwagandha on elevated zero maze and elevated plus maze paradigms was examined. Anti-anxiety potentials of these drugs w...