The thermal and Lewis acid (LA) catalyzed cyclizations of quinone 1 involved in the synthesis of Colombiasin A and Elipsaterosin B have been theoretically studied using DFT methods at the B3LYP/6-311G(d,p) computational level. B3LYP calculations suggest that the formal endo [4 + 2] cycloadduct allowing the synthesis of Colombiasin A is preferentially formed under thermal conditions, while in th...

A.V.V.N.K. Sunil Kumar*, T.V. Reddy and C.B. Sekaran Department of Chemistry, NRI College, Vijayawada, India-520 010 Department of Chemistry, Mallareddy College of Engineering, Secundrabad, India-500100 Department of Pharmaceutical Biotechnology & Pharmaceutical Analysis, Medarametla Anjamma Mastan Rao College of Pharmacy, Narasaraopet, India-522 601 (Received 16 August 2015, Accepted 13 Januar...

Isonicotinamides carrying N-furanylmethyl, N-pyrrolylalkyl or N-thiophenylmethyl substituents at nitrogen undergo cyclisation induced by an electrophile, giving spirocyclic compounds or doubly spirocyclic compounds in which both the nucleophilic and electrophilic heterocycles are dearomatised.

in this research work, the effects of natural fibers such as date palm fiber (df) and jute fiber (jf) on bending properties of polypropylene (pp)/ ethylene–propylene–diene–monomer (epdm) thermoplastic elastomers are investigated. for this purpose, the date palm and jute fibers at five levels of fiber weight fractions (0, 5, 10, 20 and 30 wt. %) are utilized during composite fabrication. maleic ...

The nonsteroidal anti-inflammatory agent (+ or -)-suprofen [alpha-methyl-4-(2-thienylcarbonyl)benzeneacetic acid] was evaluated as a P450 2C9 inactivator. (+ or -)-Suprofen inactivated the diclofenac-4-hydroxylase activity of baculovirus-expressed P450 2C9 in a time- and concentration-dependent manner, which was consistent with mechanism-based inactivation. The loss of activity followed pseudo-...

Despite the favorable properties that azetidine rings can engender on drug-compounds, methods for diversity-oriented synthesis of azetidine-based structures are significantly underdeveloped. Herein, we report successful realization a multicomponent [1,2]-Brook rearrangement/strain-release-driven anion relay sequence and its application to modular substituted azetidines. The rapidity reaction, a...

Chemodivergent cross-couplings are those in which either one of two (or more) potentially reactive functional groups can be made to react based on choice conditions. In particular, this review focuses involving different (pseudo)halides that compete for the role electrophilic coupling partner. The discussion is primarily organized by pairs electrophiles including chloride vs. triflate, bromide ...