Pharmacological blockade of the spontaneous electrical activity present in primary cultures of rat myotubes by growth in bupivacaine, tetrodotoxin, or KCl was found to increase the number of voltage-sensitive Na+ channels 38-83% as measured by the specific binding of [3H]saxitoxin. The inhibition of spontaneous electrical activity and increase in channel density by bupivacaine displayed an iden...

Introduction: Recent developments of radiotherapy techniques, require high accuracy detectors to determine the delivered dose in a small area. Chemical vapor deposition (CVD) or naturally growth diamond detectors which are commercially available are good candidates for this purpose. In these detectors two electrodes with high different electrical potential are deposited on both...

The activity of electrical current against planktonic bacteria has previously been demonstrated. The short-term exposure of the bacteria in biofilms to electrical current in the absence of antimicrobials has been shown to have no substantial effect; however, longer-term exposure has not been studied. A previously described in vitro model was used to determine the effect of prolonged exposure (i...

Among five potentially probiotic lactobacilli investigated, Lactobacillus plantarum MF1298 and Lactobacillus salivarius DC5 showed the highest increase in the transepithelial electrical resistance (TER) of polarized monolayers of Caco-2 cells, and this increase was shown to be dose dependent. Furthermore, preincubation with MF1298 attenuated a decrease in TER induced by Listeria monocytogenes.

Superfusion of canine tracheal mucosa with 100 microg each of grepafloxacin and ciprofloxacin per ml reduced the electrical transepithelial potential difference in vivo by more than 50%. This effect was dose dependent, specific for new quinolones, and inhibited by Cl channel blockers, indicating that new quinolones attenuate Cl secretion across the airway epithelium.

BACKGROUND: Despite preclinical evidence suggesting a synergistic interaction between ketamine and opioids promoting analgesia, several clinical trials have not identified dosing regimens capable of eliciting a benefit in the co-administration of ketamine with opioids. METHODS: Ten healthy volunteers participated in a double blinded, randomised, placebo controlled, crossover laboratory study in...

Introduction: Head scans are the most frequently performed computed tomography (CT) examinations worldwide. However, there is growing concern over the probability of increased cancer risks among the exposed populations. Diagnostic reference levels (DRLs) identify radiation dose that is not commensurate with clinical objectives. The aim of this study was to establish DR...

Introduction: In the Kindling-induced seizure model, low and repeated electrical or chemical stimulations, can elevate the neural network excitability and induce epileptiform seizures. Opioid receptors are widely distributed in different areas of the brain. On the other hand, morphine has paradoxical effects and induces elevation or alleviation of the pain sensation and excitability, at diff...

Seed of onion (Allium cepa L.) cv. Ailsa Craig were exposed to various doses of gamma radiation, i.e. 10,20.40.80. and 100 krad. Irradiation doses have no significant effect on seed viability, except the highest dose (100 krad) which resulted in reduced viabi lity. However, electrical conductivities of the leachates of seeds exposed to gamma radiation were higher than that of un irradiated seed...

Conducting polymers, also known as ‘‘synthetic metals’’, have been the subject of wide-spread investigations over the past decade due to their very promising characteristics. It was published earlier that the electrical conductivity of polyaniline (PANI) based polymer composites increases to a significant extent when irradiated to gamma, electron or UV radiation. The aim of the present study wa...