نتایج جستجو برای: edaravone
تعداد نتایج: 529 فیلتر نتایج به سال:
One of the major problems influencing the therapeutic efficacy of stem cell therapy is the poor cell survival following transplantation. This is partly attributed to insufficient resistance of transplanted stem cells to oxidative and inflammatory stresses at the injured sites. In the current study, we demonstrated the pivotal role of antioxidant levels in human umbilical cord mesenchymal stem c...
Liposomes containing ionizable cationic lipids have been widely used for the delivery of nucleic acids such as small-interfering RNA and mRNA. The utility with a permanent positive charge, however, is limited to in vitro transfection cultured cells due its dose-limiting toxic side effects observed animals. Several reports suggested that permanently charged induce reactive oxygen species (ROS) R...
BACKGROUND AND OBJECTIVE Stroke patients with severe leg paralysis are often bedridden in the acute and subacute phase, which increases the risk of disuse muscle atrophy in the chronic phase. The evidence to date indicates that oxidative stress plays an important role in the mechanism of disuse muscle atrophy. Therefore, the aim of this study was to determine if long-term radical scavenger trea...
Accumulating evidence shows that oxidative stress is involved in a wide variety of human diseases: rheumatoid arthritis, Alzheimer's disease, Parkinson's disease, cancers, etc. Here, we discuss the significance of oxidative conditions in different disease, with the focus on neurodegenerative disease including Parkinson's disease, which is mainly caused by oxidative stress. Reactive oxygen and n...
OBJECTIVE To investigate the efficacy of edaravone, a novel free radical scavenger, on preventing steroid-induced osteonecrosis (ON) in a rabbit model. METHODS Thirty-six New Zealand white rabbits were divided into control (C; n = 6), steroid-administered (S; n = 15) and edaravone-administered groups (E; n = 15) after receiving an established protocol of steroid-induced ON. Before and after s...
in Murine Hindlimb Hori K, +Tsujii M, Iino T, Satonaka H, Uemura T, Nishimura A, Akeda K, Hasegawa M, Sudo A Department of Orthopaedic Surgery, Graduate School of Medicine Mie University [email protected] Introduction Ischemia-reperfusion (I/R) injury refers to damage tissue caused when blood returns to the tissue after a period of ischemia. Reperfusion triggers a cascade of acute i...
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