Although tolerance to cannabinoids has been well established, the question of cannabinoid dependence had been very controversial until the discovery of a cannabinoid antagonist, SR141716A. The objective of this study was to develop and characterize a mouse model of precipitated withdrawal indicative of cannabinoid dependence. Using a dosing regimen known to produce pharmacological and behaviora...

Objective(s): Due to unsatisfactory response or intolerable side effects of current drugs, treatment of essential tremor remains inadequate. Thus, we aimed to investigate the protective and therapeutic effects of aqueous and ethanolic extracts of Crocus sativus (saffron), and its active consistent, safranal, on the harmaline-induced tremor in mice. Materials and Methods: To induce tremor, harma...

SECTION 1 A 57-year-old man presented with progressive difficulty in walking for 2 weeks, resting hand tremors for 1 week, and low-volume speech for 2 days. Initially, he had difficulty in initiation of walking. Soon, he developed shortstepped gait with history of en bloc falling forward. Within 2 weeks of the onset of illness, he became bedbound. While in bed, he remained very stiff and could ...

Non-volcanic deep low-frequency tremors in southwest Japan exhibit a strong temporal and spatial correlation with slow slip detected by the dense seismic network. The tremor signal is characterized by a low-frequency vibration with a predominant frequency of 0.5–5 Hz without distinct Por S-wave onset. The tremors are located using the coherent pattern of envelopes over many stations, and are es...

Objective: To report a case of serotonin syndrome, with episodic worsening course, which responded to treatment with cyproheptadine. Case Report: A 56 year old male, was diagnosed as a case of bipolar affective disorder, hypertension and generalized seizure disorder. While receiving a combination of lithium carbonate 750 mg/d, amlodipine 10 mg/d, phenytoin 300mg/d, sertraline 100 mg/d, trazodon...

INTRODUCTION Tremulous jaw movement (TJMs) in rats can be induced pharmacologically by striatal dopaminergic manipulation or electrolytic lesion of ventrolateral striatum (VLS). This tremor has neurochemical, anatomical and electromyographic (EMG) characteristics similar to those of tremor in Parkinson patients. However, the EMG characteristics of tremors generated by electrolytic lesion to the...