Does goal directed therapy in the emergency department (ED) improve outcomes in patients with severe sepsis and septic shock? Knoblich B, et al. Early goal-directed therapy in the treatment of severe sepsis and septic shock. Objective To determine whether early goal-directed therapy (EGDT) before admission to the intensive care unit reduces the incidence of multiorgan dysfunction, mortality and...

Sepsis is associated with a high incidence of mortality and morbidity, however with appropriate strategies for monitoring and early targeted intervention mortality rates decline. This article examines the basic pathophysiology of the inflammatory response to tissue injury and the effects this has on circulation. A partnership of the Society of Critical Care Medicine, the European Society of Int...

This study was conducted to find out the group B streptococcus colonisation of pregnant women in Kocaeli, Turkey. A culture plus individualised high-risk-based antibiotic prophylaxis was compared with high-risk-based approach alone. The screening of women was performed via vaginal and anal cultures for group B streptococcus (GBS). The maternal GBS colonisation rate was found to be 6.5%. All col...

Background: Sepsis is a highly complex and fatal syndrome, considered to be the main cause of death in intensive care unit. Early diagnosis beneficial reduce mortality improve prognosis patients. Therefore, we look forward finding cheap fast diagnostic criteria quickly assess patient’s condition. Methods: Our study enrolled 499 patients our hospital from January 2020, 96 healthy cases same peri...

Sepsis is a highly lethal syndrome with heterogeneous clinical manifestation that can be hard to identify and treat. Early diagnosis appropriate treatment are critical reduce mortality promote survival in suspected cases improve the outcomes. Several screening prediction systems have been proposed for evaluating early detection of patient deterioration, but efficacy still limited at individual ...

OBJECTIVE Sepsis is a serious condition with high mortality. Early treatment improves outcome and can be initiated by emergency medical services (EMS) personnel.The primary aim of our study was to investigate how many sepsis patients are transported by EMS to the internist at the emergency department (ED). The secondary aims were to compare these EMS patients with patients who arrived at the ED...

Introduction Hyperlactatemia is often associated with poor clinical outcomes. Mortality is increased when lactic acidosis with low-flow states or sepsis. For improving poor prognosis, early detection and intervention of hyperlactatemia are important. There are call for monitoring blood lactate level. However, hyperlactatemia is often associated with type II lactic acidosis in hemato-oncologic m...

BACKGROUND Early onset sepsis remains a major cause for neonatal morbidity and mortality. OBJECTIVES The aim of this study was to describe and compare the clinical and laboratory characteristics of neonates in neonatal intensive care unit with culture positive and negative early onset sepsis and verify if there were any differences between the groups. METHODS A one year comparative prospect...

Sepsis is defined as the combination of pathologic infection and physiological changes known collectively as the systemic inflammatory response syndrome (Martin, 2003). This response results in physiological alterations that occur at the capillary endothelial level. In the early stages, the clinical manifestations of this process are unspecific and it is often underappreciated in clinical pract...

PURPOSE Patients with severe sepsis who experience rapid, early deterioration and death are of particular concern. Our objective was to identify predictors of early death in Emergency Department (ED) patients with severe sepsis. METHODS Secondary analysis of two prospective studies of adult ED patients with severe sepsis. The primary outcome was early death, defined as death within 24h of tri...