The ability of Candida albicans to invade mucosal tissues is a major virulence determinant of this organism; however, the mechanism of invasion is not understood in detail. Proteolytic breakdown of E-cadherin, the major protein in epithelial cell junctions, has been proposed as a mechanism of invasion of certain bacteria in the oral mucosa. The objectives of this study were (i) to assess whethe...

Background The purpose of the present study was to evaluate relationship between chronic endometritis and epithelial-mesenchymal transition in endometrium infertile patients implantation phase. Methods Endometrial biopsy specimens from 66 infertility were analyzed. presence investigated by immunostaining for CD138. Immunohistochemical staining E-cadherin, N-cadherin, Slug, Snail performed, expr...

E-cadherin is a cell surface adhesion molecules that play an important role in tissue differentiation. FGFR1 is expressed in the developing and mature skeleton in patterns suggestive of both unique and redundant function. Expression levels of E-cadherin and FGFR1 during osteoblastogenesis unclear. In this study primary calvarial mouse osteoblasts were differentiated to mature osteoblasts in ost...

We aimed to evaluate the regulatory effects of miR-148a-3p on stem cell osteogenic differentiation and enamel development by targeting runt-related transcription factor 2 (RUNX2) E-cadherin, respectively. TargetScan software was utilized predict binding sites between marker gene RUNX2 or E-cadherin. The changes in expression during epidermal cells were detected. After transfection with mimics i...

P-Cadherin is a member of the cadherin family of cell surface glycoproteins that mediate Ca2+-dependent cell-cell adhesion and is expressed in a differential fashion in normal epithelial tissues. The expression of P-cadherin in human prostate cancer development has not been investigated previously. By immunohistochemistry, we show that P-cadherin expression is restricted to the cell-cell border...

S100A4 is known to be involved in cancer cell motility by virtue of its ability to activate nonmuscle myosin. E-cadherin has an important role in the homophilic cell-cell adhesion and is called an invasion suppressor gene. In the current study, we investigate the histological type and metastatic potential of gastric cancer from the aspect of the interrelationship of E-cadherin and S100A4 expres...

BACKGROUND Loss of E-cadherin expression has been implicated in the development of invasive characteristics in colorectal carcinomas. Failure to express E-cadherin may result from mutations of the E-cadherin gene (HSECAD). AIMS To examine the correlation between E-cadherin expression and genetic changes at HSECAD; and to examine differences in E-cadherin expression and genetic changes at HSEC...

Background: MicroRNA (miR) has been suggested in the development of several types cancer; yet, exact function miR-4284 colon cancer remains elusive.
 Methods: MiR-4284 expression was assessed normal cell line CCD-18Co, and HT-29 SW480 lines representing human cancer. Potential target gene predicted using TargetScanHuman, experimentally verified luciferase report assay. Wound-healing, invas...

We have produced null mutant mouse embryonic stem cells for the cell adhesion molecule E-cadherin. Such E-cadherin-/- ES cells are defective in cell aggregation; this defect can be corrected by transfection with cDNA for either E-cadherin or N-cadherin driven by a constitutive promoter. The presence (or absence) of E-cadherin regulates the expression of the transcription factor T-brachyury, ind...