OBJECTIVE This randomised, double blind, placebo controlled, two parallel group study was conducted to assess the beneficial effect of injection of botulinum toxin A (Dysport) into the subscapularis muscle on shoulder pain in stroke patients with spastic hemiplegia. METHODS A single dose of botulinum toxin A (500 Speywood units) or placebo was injected into the subcapularis muscle. Pain was a...

Palatal myoclonus is a rare condition in which there are rhythmic jerky movements of the soft palate and sometimes of the other muscles innervated by the brainstem A particularly annoying symptom is a rhythmic clicking sound in the ear due to the opening and closing of the Eustachian tube. Orofacial buccal dystonia is a focal dystonia with sustained spasms of the masticatory, facial or lingual ...

INTRODUCTION Submucoperichondrial injection of botulinum neurotoxin A (BTA) in the nasal septum is a promising therapeutic option in the treatment of persistent allergic rhinitis (AR) and non-allergic rhinitis, and is safer and more effective than intraturbinate injection in reducing clinical symptoms. MATERIALS AND METHODS Forty patients diagnosed with persistent AR or non-allergic rhinitis ...

Neurogenic detrusor overactivity (NDO) can result in lower and upper urinary tract complications and eventually even in end-stage kidney failure. Since the driving force of this clinical cascade is high bladder pressure, controlling intravesical pressure in NDO patients improves both quality of life and life-expectancy in these patients. Botulinum toxin A (BTX-A) has proven its efficacy in redu...

The Gulf Journal of Dermatology and Venereology ABSTRACT Background: Although many treatments have been suggested for eccrine hydrocyctoma so far, most of them are disappointing. The autonomic inhibitory effect of botulinum toxin type-A (BT-A) can result in successful treatment of eccrine hydrocyctoma. Objective: This study was performed to evaluate the efficacy of BT-A in treatment of eccrine ...

There seems to be a genetic predisposition to primary (essential) hyperhidrosis and it often manifests itself in childhood or puberty. Essential or focal hyperhidrosis characteristically does not occur during sleep, but is made worse by heat and emotional situations, as it is considered that the hypothalamic sweat centers are more sensitive to emotional stimuli in nonhyperhidrotic subjects. 2 H...

OBJECTIVES To quantify the treatment effect of local botulinum toxin injections in writer's cramp a newly developed rating scale of writing performance and a computer assisted analysis of writing speed were used in 31 patients undergoing botulinum toxin therapy. METHODS Baseline data of the writer's cramp rating scale (WCRS, see appendix) and computer based writing speed analysis were compare...

BACKGROUND There are several commercially available neurotoxins to improve facial aesthetics, but few prospective, randomized trials have been conducted without commercial support to compare these agents. OBJECTIVES The authors present the results of a study examining and comparing the effects of onabotulinumtoxinA (BoNT-ONA; Botox, Allergan, Inc., Irvine, California) and abobotulinumtoxinA (...

OBJECTIVE To examine goal attainment scaling for evaluation of treatment for upper limb post-stroke spasticity with botulinum toxin-A. DESIGN Secondary analysis of a multi-centre double-blind, placebo-controlled randomized clinical trial. SETTING Six outpatient clinics in Australia. PARTICIPANTS Patients (n=90) completing per protocol 2 cycles of treatment/placebo. Mean age 54.5 (standard...

Sialorrhea or excessive salivation, and drooling, are common and disabling manifestations in different neurological disorders. A review is made of the literature, based on a PubMed search, selecting those articles describing clinical trials involving the injection of botulinum toxin A in the salivary glands of patients with different diseases characterized by sialorrhea. The most frequently tre...