BACKGROUND Derivation of dose-volume correlated with toxicity for multi-modal treatments can be difficult due to the perceived need for voxel-by-voxel dose accumulation. With data available for a single-institution cohort with long follow-up, an investigation was undertaken into rectal dose-volume effects for gastrointestinal toxicities after deformably-registering each phase of a combined exte...

The primary application of Image Guided Radiotherapy (IGRT) in the treatment of localized prostate cancer has been to assist precise dose delivery to the tumor. With the ability to use in-room Computed Tomography (CT) imaging modalities, the prostate, bladder and rectum can be imaged before each treatment and the actual doses delivered to these organs can be tracked using anatomy of the day. Th...

PURPOSE The purpose of this study is to evaluate the correlation between the conventional plan parameters and dosimetric parameters obtained from conformal radiotherapy (RT) planning, and between these parameters and radiation pneumontitis (RP) incidence. METHODS Clinical and dosimetric data of 122 patients that were treated with mastectomy and adjuvant 3D conformal RT (39% received 2-field R...

The purpose of this study is to find the uncertainties in the reconstruction of MR compatible ring-tandem intracavitary applicators of high-dose rate image-based brachytherapy treatment planning using rigid registration of 3D MR and CT image fusion. Tandem and ring reconstruction in MR image based brachytherapy planning was done using rigid registration of CT and MR applicator geometries. Verif...

PURPOSE The aim of this study is to compare 3D dose volume histogram (DVH) parameters of bladder and other organs at risk with different bladder filling protocol during high-dose-rate intracavitary brachytherapy (HDR-ICBT) in cervical cancer, and to find optimized bladder volume. MATERIAL AND METHODS This dosimetric study was completed with 21 patients who underwent HDR-ICBT with computed tom...

PURPOSE To calculate the normal tissue complication probability (NTCP) of late radiation effects on the rectum and bladder from repetitive CT scans during fractionated high-dose-rate brachytherapy (HDRB) and external beam radiotherapy (EBRT) of the uterine cervix and compare the NTCP with the clinical frequency of late effects. METHODS AND MATERIALS Fourteen patients with cancer of the uterin...

Definitive treatment for cervical cancer most often consists of fractionated external beam radiotherapy combined with multi-fraction intracavitary brachytherapy. CT imaging in gynaecological brachytherapy treatment planning has been widely used in the past decade. With the advantages of image-based treatment planning and the commercial treatment planning software tools available, it is possible...