Background/Aim: Long-term acid suppressants are known to have adverse effects. Its effect on gastric mucosa is not known. A cross-sectional study was undertaken to study the effect of Helicobacter pylori on gastric mucosa among patients on longterm acid suppressants. Materials and methods: One hundred and twenty-six patients with symptoms of ulcer type dyspepsia and reflux type dyspepsia for mo...

The ileal mucosa of Crohn disease (CD) patients is abnormally colonized by adherent-invasive E. coli (AIEC) that are able to adhere to and invade intestinal epithelial cells. Here, we show that CD-associated AIEC strains adhere to the brush border of primary ileal enterocytes isolated from CD patients but not controls without inflammatory bowel disease. AIEC adhesion is dependent on type 1 pili...

oral malignant melanoma (omm) accounts for 5% of all oral malignancies. it is a rare aggressive neoplasm usually found on the hard palate and gingiva. the etiology is unknown, but tobacco and chronic irritation are suggested as probable causative factors. over 30% of the cases have been reported to arise from pre-existing pigmented lesions. a biopsy is required to establish the diagnosis and th...

BACKGROUND Therapeutic hypothermia during operation decreases postoperative intra-abdominal adhesion formation. We sought to determine the most appropriate duration of hypothermia, and whether hypothermia affects the expression of tissue plasminogen activator (tPA). METHODS 80 male BALB/c mice weighing 25-30 g are randomized into one of five groups: adhesion model with infusion of 15°C saline...

objectives: postsurgical adhesion is one of the common complications after surgery. some anti-adhesion barriers are commercially available which are not customary used by physicians as much as expected because of ineffectiveness. recently, nanofibers have been introduced as anti-adhesion barriers with the potential of drug delivery. in the light of role of inflammation and oxidative stress in a...

background: celiac disease (cd), as an autoimmune disease has initiated since ingestion of food containing gluten. constant intolerance to gluten causes damages of the small intestinal mucosa. one reason of mal-absorption in children and infants is cd. additionally, about 75% of newly identified patients with cd have low bone mineral density (bmd). many factors have role in metabolic bone disea...

atherosclerosis is a chronic inflammatory condition. many pro-inflammatory factors including interleukin-6 (il-6), tumor necrosis factor-α (tnf-α), c-reactive protein (crp), and adhesion molecules including intercellular adhesion molecule (icam-1) and vascular cell adhesion molecule (vcam-1) are expressed in atherosclerotic lesions. the plants of genus vaccinium are rich in anthocyanins with an...

Khat (Catha Edulis Forskal) is widely cultivated in Yemen and East of Africa. The habit of chewing tender leaves and twigs of khat is deep-rooted in Yemen. Our study investigates the chronic khat chewing and smoking effect on oral mucosa. The sample (n=79) consists of two main groups, khat chewers (n=54) and control groups (n=25). Khat chewers group is divided into 4 subgroups according to dura...

BACKGROUND Diabetes mellitus is a chronic degenerative systemic disease whose prevalence is increasing. This paper aims to evaluate the effects of diabetic microangiopathy, depending on its duration and the type of treatment administered, by using polarized light videocapillaroscopy of the oral mucosa. MATERIAL AND METHODS We enrolled 120 subjects: 60 healthy subjects and 60 patients with diabe...