The present work is aimed at evaluating the antitumour properties of a Pd(II) dinuclear complex with the biogenic polyamine spermine, by investigating: i) the anti-angiogenic and anti-migration properties of a Pd(II) dinuclear complex with spermine (Pd2Spm); ii) the anti-proliferative activity of Pd2Spm against a triple negative human breast carcinoma (MDA-MB-231); and finally iii) the putative...

Combinations of drugs promoting anti-angiogenesis and apoptosis effects are meaningful for cancer therapy. In the present study, dual peptides-modified liposomes were designed by attaching two receptor-specific peptides, specifically low-density lipoprotein receptor-related protein receptor (Angiopep-2) and neuropilin-1 receptor (tLyP-1) for brain tumor targeting and tumor penetration. Vascular...

To prepare an efficient theranostic polyphosphazene-docetaxel (DTX) conjugate, a new drug delivery system was designed by grafting a multifunctional lysine ethylester (LysOEt) as a spacer group along with methoxy poly(ethylene glycol) (MPEG) to the polyphosphazene backbone ([NP]n), and then DTX was conjugated to the carrier polymer using acid-cleavable cis-aconitic acid (AA) as a linker. The re...

CD44 and CD147 are associated with cancer metastasis and progression. Our purpose in the study was to investigate the effects of down-regulation of CD44 or CD147 on the metastatic ability of prostate cancer (CaP) cells, their docetaxel (DTX) responsiveness and potential mechanisms involved in vitro and in vivo. CD44 and CD147 were knocked down (KD) in PC-3M-luc CaP cells using short hairpin RNA...

Digital therapeutics (DTx) have been defined as technologies that “offer therapeutic interventions driven by high-quality software programs, based on scientific evidence obtained through methodologically rigorous confirmatory clinical investigation, to prevent, manage and treat a broad spectrum of physical, mental behavioural conditions”. DTx products are the market in number countries or … Con...

Patients with advanced prostate cancer (PCa) invariably develop resistance to anti-androgen therapy and taxane-based chemotherapy. Glucocorticoid receptor (GR) has been implicated in PCa resistance; however, the mechanisms underlying GR-mediated chemoresistance remain unclear. Lens epithelium-derived growth factor p75 (LEDGF/p75, also known as PSIP1 DFS70) is a glucocorticoid-induced transcript...

With the advent of digital therapeutics (DTx), development software as a medical device (SaMD) for mobile and wearable devices has gained significant attention in recent years. Existing DTx evaluations, such randomized clinical trials, mostly focus on verifying effectiveness products. To acquire deeper understanding engagement behavioral adherence, beyond efficacy, large amount contextual inter...

One of the few positive outcomes ongoing COVID-19 pandemic is that it has enhanced pace digitalisation healthcare. Among various facets digital health, Digital Therapeutics (DTx) unique as offers evidence-based interventions for preventing, managing, or treating specific disorders. It different from wellness apps because requires evidence a clinical trial real-world settings and bound by regula...

LATEX packages made available from CTAN are commonly distributed as a pair of files: 〈something〉.ins and 〈something〉.dtx. The user is then instructed to run the .ins file through latex to produce the actual package files. What are these .ins and .dtx files? How do you, as a class or style-file writer, create your own? And, why would you want to? This article answers those questions and elucidat...

Nonspecific back pain (NSBP) contributes greatly to the overall burden of disease from musculoskeletal conditions. Digital therapeutics (DTx) aims address excess demand for movement and exercise therapy resulting this spectrum This study investigate differential therapeutic response NSBP different use profiles a digital home program. Methods: used PSM model comparatively assess achievement clin...