BACKGROUND The profound loss of power that occurs in skeletal muscle after electrical conditioning has been the major limiting factor in its clinical application. This study investigates a 3-fold approach for chronic conditioning of skeletal muscle ventricles (SMVs) combining electrical transformation, dynamic training against systemic load, and pharmacological support with clenbuterol. METHO...

Time-dependent integrated predictive modelling is carried out using the PTRANSP code to predict fusion power and parameters such as alpha particle density and pressure in ITER H-mode plasmas. Auxiliary heating by negative ion neutral beam injection and ion-cyclotron heating of He 3 minority ions are modelled, and the GLF23 transport model is used in the prediction of the evolution of plasma tem...

We present a model of exclusive $\phi$-meson lepto-production $ep \to e'p'\phi$ near threshold which features the strangeness gravitational form factors proton. argue that shape differential cross section $d\sigma/dt$ is sensitive probe D-term

Doubling time (DT) is widely used for quantification of tumor growth rate. DT is usually determined from two volume estimations with measurement time intervals comparable with or shorter than DT. Clinical data show that the frequency distribution of DT in patients is positively skewed, with some very long DT values compared with the average DT. Growth rate can also be quantified using specific ...

BACKGROUND Diffusion tensor magnetic resonance imaging (DT MRI) has the potential to provide in vivo information about tissue microstructure. In multiple sclerosis (MS), DT MRI has disclosed the presence of occult structural damage in the normal-appearing brain tissues. OBJECTIVE To investigate whether DT MRI is sensitive to longitudinal changes of brain damage that may occur beyond the resol...

Doubling time (DT) is widely used for quantification of tumor growth rate. DT is usually determined from two volume estimations with measurement time intervals comparable with or shorter than DT. Clinical data show that the frequency distribution of DT in patients is positively skewed, with some very long DT values compared with the average DT. Growth rate can also be quantified using specific ...

Despite their practical and commercial relevance, there are few reports on the kinetics of growth and production of Chinese hamster ovary (CHO) cells-the most frequently used host for the industrial production of therapeutic proteins. We characterize the kinetics of cell growth, substrate consumption, and product formation in naive and monoclonal antibody (mAb) producing recombinant CHO cells. ...

It is well known that in the case where the stock price St is governed by the equation dSt/St = μdt + σdWt, any European option satisfying weak regularity conditions has a fair price (the Black—Scholes formula and its generalizations). We consider the case where no probabilistic assumptions are made about St; instead, we assume that the derivative security D which pays a dividend of (dSt/St) (t...

For an odd prime p, an even integer n, and d = p + 1 with gcd(n, k) = 1, there are p + 1 distinct decimated sequences s(dt + l), 0 ≤ l < p + 1, for a p-ary m-sequence s(t) of period p − 1 since gcd(d, p − 1) = p + 1. In this paper, the cross-correlation distribution between a p-ary m-sequence s(t) and its p+1 distinct decimated sequences s(dt+l) is derived. The maximum magnitude of their cross-...

Glucose-dependent insulinotropic polypeptide (GIP) and GLP-1 are incretins secreted by respective K and L enteroendocrine cells after eating and amplify glucose-stimulated insulin secretion (GSIS). This amplification has been termed the "incretin response." To determine the role(s) of K cells for the incretin response and type 2 diabetes mellitus (T2DM), diphtheria toxin-expressing (DT) mice th...