P pili are hair-like adhesive structures that are assembled on the outer membrane (OM) of uropathogenic Escherichia coli by the chaperone-usher pathway. In this pathway, chaperone-subunit complexes are formed in the periplasm and targeted to an OM assembly platform, the usher. Pilus subunits display a large groove caused by a missing β-strand which, in the chaperone-subunit complex, is provided...

Introduction Rapid chemical shift imaging (CSI) techniques are of considerable interest for hyperpolarized C metabolic imaging [1,2]. Undersampled spiral CSI (spCSI) using a free induction decay (FID) acquisition mode has been applied to real-time metabolic imaging with acquisition times of less than 1 s per slice [3]. The FID acquisition necessitates phase correction during reconstruction for ...

We introduce Deep Semantic Embedding (DSE), a supervised learning algorithm which computes semantic representation for text documents by respecting their similarity to a given query. Unlike other methods that use singlelayer learning machines, DSE maps word inputs into a lowdimensional semantic space with deep neural network, and achieves a highly nonlinear embedding to model the human percepti...

We propose an abstract framework for Design Space Exploration (DSE) in the context of model-based embedded system development. The goal is to enable the integration of a set of concrete DSE methods addressing different system characteristics and design goals while still having a common understanding of design artifacts.

The endocannabinoid 2-arachidonoylglycerol (2-AG) mediates retrograde synaptic depression including depolarization-induced suppression of excitation (DSE) and inhibition (DSI). 2-AG is degraded primarily by monoacylglycerol lipase (MAGL), which is expressed in neurons and astrocytes. Using knockout mice in which MAGL is deleted globally or selectively in neurons or astrocytes, we investigated t...

The primary aims of this paper were (1) to evaluate the influence of intensive lifestyle weight loss and exercise intervention (ILI) compared with diabetes support and education (DSE) upon Heart Rate Recovery (HRR) from graded exercise testing (GXT) and (2) to determine the independent and combined effects of weight loss and fitness changes upon HRR. In 4503 participants (45-76 years) who compl...

â  monetary policy rule is an approach to avoid time inconsistency problem as regarded by new classical economist to choose a time plan for policy making in order to maximize households’ well-being. the foundation of time inconsistency problem is not coincidence of expectations as an ex-ante variable, which is expected variable, with actual variable as an ex-post variable. expectations in fin...

Abstract Funding Acknowledgements Type of funding sources: None. Introduction. Takotsubo cardiomyopathy (TTC) mimics an acute coronary syndrome and corresponds to reversible stress-induced cardiomyopathy. Dobutamine Stress Echocardiography (DSE) has been widely used for more than 30 years is considered as one the gold standard non-invasive test detect myocardial ischemia. DSE responsible a TTC ...

The problems of population referral bias in the calculation of specificity in diagnostic testing for coronary artery disease have been previously described. Previous studies investigating the sensitivity and specificity of dobutamine stress echocardiography (DSE) have been subject to pretest and posttest referral biases, largely as a result of the requirement for coronary arteriography. This st...

BACKGROUND The analysis of wall motion abnormalities with dobutamine stress echocardiography (DSE) is an established method for the detection of myocardial ischemia. With ultrafast magnetic resonance tomography, identical stress protocols as used for echocardiography can be applied. METHODS AND RESULTS In 208 consecutive patients (147 men, 61 women) with suspected coronary artery disease, DSE...