نتایج جستجو برای: drug protein interaction

تعداد نتایج: 2187662  

Journal: :Current Drug Targets 2009

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Journal: Iranian Journal of Pharmaceutical Research 2011
Arvin Medhet Ellaheh Noshinfar, Mostafa Rezaei-Tavirani, Roya Tadayon, Said Namaki, Seyed Alireza Mortazavi, Shiva Kalantari

Human serum albumin (HSA) is an important protein that carries variety of substances like some hormones and drugs in blood. Pharmacological studies of the interaction of many drugs and HSA are reported during several decades, specially recently years. Interaction of cortisol and fluoxetine hydrochloride (FLX) (as a common anti-stress drug) with HSA (as their carrier in blood) has been studied s...

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Journal: :PLoS Computational Biology 2009

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Journal: :Angewandte Chemie 2023

Targeted protein upregulation by modulating the interaction between a target and its E3 ligase is strategy opposite to targeted degradation (PROTAC). In their Research Article (e202300978), Dong-Sup Lee, Seung Bum Park enhanced cellular STING levels inhibiting STING-TRIM29 interaction, which activates innate immune responses in tumor microenvironment potentiates immune-oncology treatment changi...

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Journal: :MEDS Chinese medicine 2023

The aim of this study was to predict the mechanism action Baohe Pill in treatment functional dyspepsia using network pharmacology. Predict main active ingredients and targets by TCMSP platform database Traditional Chinese Medicine Systematic Pharmacological Analysis Platform, convert collected drug into gene names Uniprot database; obtain FD genes GeneGards, TTD, OMIM database, use Cytoscape 3....

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Journal: The Iranian Journal of Pharmaceutical Research 2011
Arvin Medhet Ellaheh Noshinfar, Mostafa Rezaei-Tavirani, Roya Tadayon, Said Namaki, Seyed Alireza Mortazavi, Shiva Kalantari

Human serum albumin (HSA) is an important protein that carries variety of substances like some hormones and drugs in blood. Pharmacological studies of the interaction of many drugs and HSA are reported during several decades, specially recently years. Interaction of cortisol and fluoxetine hydrochloride (FLX) (as a common anti-stress drug) with HSA (as their carrier in blood) has been studied s...

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Journal: :gastroenterology and hepatology from bed to bench 0
nahid safari-alighiarloo proteomics research center, faculty of paramedical sciences, shahid beheshti university of medical sciences, tehran, iran mohammad taghizadeh bioinformatics department, institute of biochemistry and biophysics, tehran university, tehran, iran mostafa rezaei-tavirani proteomics research center, faculty of paramedical sciences, shahid beheshti university of medical sciences, tehran, iran bahram goliaei bioinformatics department, institute of biochemistry and biophysics, tehran university, tehran, iran ali asghar peyvandi hearing disorders research center, shahid beheshti university of medical sciences, tehran, iran

normal 0 false false false en-us x-none ar-sa microsoftinternetexplorer4 the physical interaction of proteins which lead to compiling them into large densely connected networks is a noticeable subject to investigation. protein interaction networks are useful because of making basic scientific abstraction and improving biological and biomedical applications. based on principle roles of proteins ...

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Journal: :Okayama Igakkai Zasshi (Journal of Okayama Medical Association) 2014

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Journal: :Okayama Igakkai Zasshi (Journal of Okayama Medical Association) 2018

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Journal: :Scientific Reports 2017

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نمودار تعداد نتایج جستجو در هر سال

با کلیک روی نمودار نتایج را به سال انتشار فیلتر کنید

function paginate(evt) { url=/search_year_filter/ var term=document.getElementById("search_meta_data").dataset.term pg=parseInt(evt.target.text) var data={ "year":filter_year, "term":term, "pgn":pg } filtered_res=post_and_fetch(data,url) window.scrollTo(0,0); } function update_search_meta(search_meta) { meta_place=document.getElementById("search_meta_data") term=search_meta.term active_pgn=search_meta.pgn num_res=search_meta.num_res num_pages=search_meta.num_pages year=search_meta.year meta_place.dataset.term=term meta_place.dataset.page=active_pgn meta_place.dataset.num_res=num_res meta_place.dataset.num_pages=num_pages meta_place.dataset.year=year document.getElementById("num_result_place").innerHTML=num_res if (year !== "unfilter"){ document.getElementById("year_filter_label").style="display:inline;" document.getElementById("year_filter_place").innerHTML=year }else { document.getElementById("year_filter_label").style="display:none;" document.getElementById("year_filter_place").innerHTML="" } } function update_pagination() { search_meta_place=document.getElementById('search_meta_data') num_pages=search_meta_place.dataset.num_pages; active_pgn=parseInt(search_meta_place.dataset.page); document.getElementById("pgn-ul").innerHTML=""; pgn_html=""; for (i = 1; i <= num_pages; i++){ if (i===active_pgn){ actv="active" }else {actv=""} pgn_li="
  • " +i+ "
    • "; pgn_html+=pgn_li; } document.getElementById("pgn-ul").innerHTML=pgn_html var pgn_links = document.querySelectorAll('.mypgn'); pgn_links.forEach(function(pgn_link) { pgn_link.addEventListener('click', paginate) }) } function post_and_fetch(data,url) { showLoading() xhr = new XMLHttpRequest(); xhr.open('POST', url, true); xhr.setRequestHeader('Content-Type', 'application/json; charset=UTF-8'); xhr.onreadystatechange = function() { if (xhr.readyState === 4 && xhr.status === 200) { var resp = xhr.responseText; resp_json=JSON.parse(resp) resp_place = document.getElementById("search_result_div") resp_place.innerHTML = resp_json['results'] search_meta = resp_json['meta'] update_search_meta(search_meta) update_pagination() hideLoading() } }; xhr.send(JSON.stringify(data)); } function unfilter() { url=/search_year_filter/ var term=document.getElementById("search_meta_data").dataset.term var data={ "year":"unfilter", "term":term, "pgn":1 } filtered_res=post_and_fetch(data,url) } function deactivate_all_bars(){ var yrchart = document.querySelectorAll('.ct-bar'); yrchart.forEach(function(bar) { bar.dataset.active = false bar.style = "stroke:#71a3c5;" }) } year_chart.on("created", function() { var yrchart = document.querySelectorAll('.ct-bar'); yrchart.forEach(function(check) { check.addEventListener('click', checkIndex); }) }); function checkIndex(event) { var yrchart = document.querySelectorAll('.ct-bar'); var year_bar = event.target if (year_bar.dataset.active == "true") { unfilter_res = unfilter() year_bar.dataset.active = false year_bar.style = "stroke:#1d2b3699;" } else { deactivate_all_bars() year_bar.dataset.active = true year_bar.style = "stroke:#e56f6f;" filter_year = chart_data['labels'][Array.from(yrchart).indexOf(year_bar)] url=/search_year_filter/ var term=document.getElementById("search_meta_data").dataset.term var data={ "year":filter_year, "term":term, "pgn":1 } filtered_res=post_and_fetch(data,url) } } function showLoading() { document.getElementById("loading").style.display = "block"; setTimeout(hideLoading, 10000); // 10 seconds } function hideLoading() { document.getElementById("loading").style.display = "none"; } -->