Mucosal-associated invariant T (MAIT) cells are an evolutionarily conserved subset of cells, which mediate functions that link innate and acquired immunity in a broad spectrum diseases, including infectious, autoimmune skin diseases. Although transcription factors such as PLZF, SATB1, miR-181a/b-1, miR-155, Drosha, SAP have been shown to regulate MAIT cell development differentiation, significa...

Abstract Most microRNAs (miRNAs) are processed by two ribonuclease III enzymes. The first cleavage is performed Microprocessor that composed of RNase enzyme Drosha and DGCR8, the second another Dicer. There many examples miRNAs poor substrates for Dicer, owing to their suboptimal structures. However, a number these known be expressed at same or higher level as neighboring structurally-optimal m...