STUDY OBJECTIVE Patients with symptomatic malignant pleural effusion are usually treated with large-bore chest tube placement and pleurodesis requiring > or = 3 days of hospitalization. We sought to demonstrate the feasibility of ambulatory drainage and sclerosis using a small-bore pigtail catheter in patients with malignant pleural effusions. We reasoned that this approach would improve sympto...

A single intradermal injection of the adjuvant-oil squalene induces T cell mediated arthritis in DA rats. The chain of events leading from nonspecific provocation of the immune system to arthritis is largely unknown. Previous studies have demonstrated that lymph node (LN) cells are of pathogenic importance, i.e. cells from LNs draining the injection site can transfer arthritis to naïve DA rats....

Lymphocytic choriomeningitis virus (LCMV) causes a systemic infection in mice with virus replication occurring in both peripheral tissues and secondary lymphoid organs. Because of the rapid systemic dissemination of the virus, the secondary lymphoid organs responsible for the induction of the LCMV-specific CD8 T cell response are poorly defined. We show that the mediastinal lymph node (MedLN) s...

A small population of plasmacytoid DCs (pDCs) in mouse tumor-draining LNs can express the immunoregulatory enzyme indoleamine 2,3-dioxygenase (IDO). We show that these IDO+ pDCs directly activate resting CD4+CD25+Foxp3+ Tregs for potent suppressor activity. In vivo, Tregs isolated from tumor-draining LNs were constitutively activated and suppressed antigen-specific T cells immediately ex vivo. ...

This work was presented in part at the 40th annual meeting of American Diabetes Association, Washington, D. C., June 1979. Diabetes. 29: 8A. (Abstr.) Receivedfor publication 2July 1980 and in revisedform 22 September 1980. 292 lymnphocytotoxicity (CML) assays revealed increases in CML before graft rejection in low MLC reactors, and decreases in both CML and MLC responses before graft rejection ...

Extra oral sinus of odontogenic origin occurs when the purulent by-products of dental pulp necrosis spread along the path of least resistance from the root apex to the skin on the face. Patients presenting with cutaneous sinus usually visit a general physician or dermatologist first, as the lesion can mimic various dermatologic pathologies, ranging from an infected sebaceous cysts to a basal ce...

In the Rouse and Zimm models, polymer dynamics are simulated by approximating the polymer by N beads which are connected to their nearest neighbours by harmonic springs. In the “free-draining” Rouse model, each bead experiences solvent friction independent of the motion of the other beads, whereas the more realistic “non-draining” Zimm model also allows for hydrodynamic interactions between the...

Here we are reporting echocardiographic findings of 8 month child with Total Anomalous Pulmonary Venous Connection (TAPVC). All pulmonary veins are draining into a venous chamber (venous confluence) posterior to Left Atrium (LA). This chamber is draining in to persistent left superior vena cava (supradiaphragmatic type) with moderate (TR) and estimated (RV) systolic pressure was 88.2 mm of Hg s...