In present study, a three-step multi-objective optimization algorithm of cyclone separators is catered for the design objectives. First, the pressure drop (Dp) and collection efficiency (h) in a set of cyclone separators are numerically evaluated. Secondly, two meta models based on the evolved Group Method of Data Handling (GMDH) type neural networks are regarded to model the Dp and h as the re...

This paper describes a new methodology for software engineering: the DP&T Methodology. It is the core component of the new DP&T System. Different from traditional methodologies with linear process models, the DP&T Methodology uses the nonlinear DP&T Model with the capacity for forward and backward traceablity. Driven by six types of automated traceability and two types of defect prevention, the...

Inulin-type fructans are the simplest and most studied fructans and have become increasingly popular as prebiotic health-improving compounds. A natural variation in the degree of polymerization (DP) of inulins is observed within the family of the Asteraceae. Globe thistle (Echinops ritro), artichoke (Cynara scolymus), and Viguiera discolor biosynthesize fructans with a considerably higher DP th...

DP-155 is a lipid prodrug of indomethacin that comprises the latter conjugated to lecithin at position sn-2 via a 5-carbon length linker. It is cleaved by phospholipase A2 (PLA)(2) to a greater extent than similar compounds with linkers of 2, 3, and 4 carbons. Indomethacin is the principal metabolite of DP-155 in rat serum and, after DP-155 oral administration, the half-life of the metabolite w...

The activity of antimetabolite inhibitors of de novo deoxyribonucleotide biosynthesis can be compromised by the salvage of extracellular preformed nucleosides and nucleobases. Dipyridamole (DP) is a nucleoside transport inhibitor that has been used clinically in an attempt to increase antimetabolite activity; however, DP binds tightly to the serum protein alpha1-acid glycoprotein (AGP) thereby ...

Background & Aims: Excessive stress in addition to causing physical and psychological problems in General Practitioners (GPs), can lead to decreased quality of patient care. This research aimed to find the frequency of burnout in general practitioners of Kerman city. Methods: This descriptive analytic study was carried out on 150 GPS in Kerman city in 2009. Data gathering was done by Maslach qu...

We found a population of nonlymphoid cells expressing both CD4 and CD8 in peripheral blood mononuclear cells (PBMCs) of human T-cell leukemia virus type-I pX transgenic rats with autoimmune diseases. These cells, which showed a monocytic phenotype, were also found in wild-type rats, and their number increased by adjuvant-assisted immunization. GM-CSF increased the number of these double-positiv...

Background This population-based study evaluated changes in glucose metabolism after distal pancreatectomy (DP). Methods Data from the Taiwan National Health Insurance Research Database was collected from 2001 to 2010. Of 1,980 patients who underwent DP, 507 had diabetes and 1,410 did not. Results Of the 1,410 non-diabetic pre-DP patients, 312 (22.1%) developed newly-diagnosed diabetes afte...