نتایج جستجو برای: doxycycline hyclate
تعداد نتایج: 5120 فیلتر نتایج به سال:
OBJECTIVES To compare the efficacy of gentamicin for 5 days plus doxycycline for 8 weeks with streptomycin for 2 weeks plus doxycycline for 45 days in the treatment of human brucellosis. METHODS In each arm of the study, 82 patients older than 10 years randomly received 5 mg/kg gentamicin once daily for 5 days plus 100 mg of doxycycline twice daily for 8 weeks or 1 g of streptomycin intramusc...
OBJECTIVE To assess tear and plasma concentrations of doxycycline following oral administration to northern elephant seals (Mirounga angustirostris). DESIGN Pharmacokinetic study. ANIMALS 18 juvenile northern elephant seals without signs of ocular disease. PROCEDURES Study seals were receiving no medications other than a multivitamin and were free from signs of ocular disease as assessed ...
Doxycycline, a tetracycline-based antibiotic, has been reported to attenuate melanoma cell migration through inhibiting the focal adhesion kinase (FAK) signaling pathway. However, it remains to be elucidated whether doxycycline exerts this effect on leukemia cell migration. The present study aimed to examine the role of doxycycline in leukemia cell migration. The invasion capacities of the huma...
Background and Aims: In spite of the advances achieved in the field of dentin adhesives, the longevity of bond to dentin is still a challenge. According to recent studies, Matrix Metaloproteinase (MMP) inhibitors can increase clinical longevity of bonding and decrease leakage. The aim of this study was to evaluate the amount and pattern of doxycycline release from an experimental dentin adhesiv...
A clinical comparison of Azithromycin versus Doxycycline in non-surgical periodontal treatment of smokers Dr. Chitsazi, M.T.* - Dr. Lafzi, A.** - Dr. Eskandari, A.*** - Dr. Mortazavi, A.**** *Associate Professor of Periodontics Dept., Faculty of Dentistry, Tabriz University of Medical Sciences. **Professor of Periodontics Dept., Faculty of Dentistry, Tabriz University of Medical Sciences. ***As...
Since their original discovery in 1948, tetracycline antibiotics have had a major impact on human health and molecular biology [1]. Beyond their efficacy against a variety of infectious diseases, insights into resistance and discovery of the tetracycline repressor system has yielded an invaluable tool for the inducible control of gene expression. Though originally characterized as selective inh...
Matrix metalloproteinases (MMPs) may have a role in the process of aseptic loosening. Doxycycline has been shown to inhibit MMPs. Our aim was to investigate the potential pharmacological effect of doxycycline on aseptic loosening. We used radiolabelled mouse calvariae cultured with human interface membrane cells from aseptically loosened hips. Bone resorption was confirmed in this model. The ef...
Statement of Problem: Chronic periodontitis is one of the most prevalent periodontal diseases in the world which may be treated through surgical or non-surgical approaches.Purpose: The aim of this study was to compare the efficacy of Doxycycline and placebo following SRP in non-surgical treatment of chronic periodontitis.Materials and Methods: This double blind interventional study was conducte...
BACKGROUND The primary aim of this study is to demonstrate the feasibility of utilizing doxycycline to suppress matrix metalloproteinase-9 (MMP-9) in brain arteriovenous malformations (AVMs). METHODS Ex-vivo treatment of AVM tissues: Intact AVM tissues were treated with doxycycline for 48 hours. Active and total MMP-9 in the medium were measured. Pilot trial: AVM patients received either doxy...
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