Bronchial asthma (BA) is a common and potentially serious chronic illness in childhood. It imposes substantial burden on the community, patients, their families, pulmonary function tests variability post-bronchodilator reversibility are useful diagnostic tools. Folate an essential water-soluble vitamin found various foods supplements food fortifiers as folic acid. A diet high folate or acid can...

Background: An elevated homocysteine level is an independent risk factor for cardiovascular disorders. Psoriatic patients have an increased risk of cardiovascular diseases; In addition, hyperhomocysteinemia is a complication of methotrexate treatment. We undertook a study to evaluate the plasma levels of homocysteine, vitamin B12 and folate in patients with psoriasis before and after short-term...

BACKGROUND A quantitative understanding of human folate metabolism is needed. OBJECTIVE The objective was to quantify and interpret human folate metabolism as it might occur in vivo. DESIGN Adults (n = 13) received 0.5 nmol [(14)C]pteroylmonoglutamate (100 nCi radioactivity) plus 79.5 nmol pteroylmonoglutamate in water orally. (14)C was measured in plasma, erythrocytes, urine, and feces for...

The concentration of folate in erythrocytes was determined using a two-phase ligandbIndIng radloasuy procedure described previously for measuring serum folate. The mean (± SD) folate concentration In erythrocytes of 20 normal subjects was 210 * 67 ng/mI. In 12 patients clinically folate deficient who had normal serum B2 concentration, the mean (± SD) erythrocyte folate was 71 * 39 ng/ml. Incuba...

We examined the effect of parental folate deficiency on the folate content, global DNA methylation, folate receptor-alpha (FRα), insulin-like-growth factor-2 (IGF-2) and -1 receptor (IGF-1R) in the liver and plasma homocysteine in the postnatal rat. Male and female rats were randomly fed a folic acid-deficient (paternal folate-deficient, PD and maternal folate-deficient, MD), or folic acid-supp...

I. A study was made on the folate content of goat’s milk in relation to stage of lactation, and on the interrelationship between blood and milk folate concentrations in the dam and in the kid. 2. In seven goats the folate concentration in the colostrum at parturition ranged from 136 to 300 ng/ml, and averaged 205 ng/ml. The concentration fell sharply during the early days of lactation and by da...

Folate functions in multiple coenzyme forms in acceptance, redox processing and transfer of one-carbon units, including nucleotides and certain amino acids. Folate-requiring metabolic processes are influenced by folate intake, intake of other essential nutrients, including vitamins B-12 and B-6, and at least one common genetic polymorphism. Estimates of folate requirements have been based on in...

The dairy starter bacterium Lactococcus lactis is able to synthesize folate and accumulates >90% of the produced folate intracellularly, predominantly in the polyglutamyl form. Approximately 10% of the produced folate is released into the environment. Overexpression of folC in L. lactis led to an increase in the length of the polyglutamyl tail from the predominant 4, 5, and 6 glutamate residues...

The main objective of this study was to assess the association between dietary fiber intake and the folate status of Canadian female adolescents. We also assessed dietary folate intakes and evaluated the prevalence of biochemical folate deficiency in these subjects. Female adolescents aged 14-19 y (n = 224) were recruited and fasting blood samples were collected. Dietary intakes (3-d food recor...