Down syndrome is the most common autosomal chromosomal disorder with incidence ranging from 1 in 700 to 1:1,000 live births [1]. The protean manifestation are mental retardation, congenital heart disease, and risk for early death. The predominant cause of death is related to the congenital heart defects followed by hypothyroidism, respiratory infections, and malignancy (particularly, leukemia) ...

Sleep disorders are common, often overlooked problem in Down syndrome, particularly during childhood. Comorbidities such as congenital heart disease often present early and management of these needs to take priority. However, this can result in the lack of early development of good sleep habits and may also lead to the perception that sleep issues are an expected problem in children with Down s...

objectives: stigma is a negative value. many behaviors are to ward stigmatized people. down syndrome is one of conditions with stigma. the aim of this study is to determine the sources of labeling in iranian down syndrome. methods: the view of 105 down syndrome families concerning stigma were conducted. all of down syndrome was under 50 years. results: a fair proportion of down syndrome familie...

abstract isolated tuberculosis (tb) liver abscesses have rarely been documented in the literature.this report describes the challenging diagnosis of primary liver tb. we report on the case of a 10-year-old girl with down syndrome, who had symptoms of fever and chills, anorexia and intermittent vomiting. the ultrasound and computed tomography (ct)revealed multiple abscess-like lesions in the liv...

PURPOSE To investigate the development of refractive errors and strabismus in a cohort of children with Down syndrome. METHOD Data for 55 children with Down syndrome who are participating in this longitudinal study of visual development, first examined by us when aged less than 2 years and on at least two other occasions, were analyzed. Mohindra retinoscopy was used to measure refractive erro...