The discovery of microRNAs (miRNAs) provides a new and powerful tool for studying the mechanism, diagnosis and treatment of human cancers. Currently, down-regulation of tumor suppressive miRNAs by CpG island hypermethylation is emerging as a common hallmark of cancer. Here, we reported that the down-regulation of miR-33b was associated with pM stage of gastric cancer (GC) patients. Ectopic expr...

BACKGROUND Nucleic acid amplification plays an increasingly important role in genetic analysis of clinical samples, medical diagnostics, and drug discovery. We present a novel quantitative PCR technology that combines the advantages of existing methods and allows versatile and flexible nucleic acid target quantification in clinical samples of widely different origin and quality. METHODS We mo...

BACKGROUND The applicability of microarray-based transcriptome massive analysis is often limited by the need for large amounts of high-quality RNA. RNA arbitrarily primed PCR (RAP-PCR) is an unbiased fingerprinting PCR technique that reduces both the amount of initial material needed and the complexity of the transcriptome. The aim of this study was to evaluate the feasibility of using hybridiz...

We investigate the effect of pair creation on a shock structure. Actually, particles accelerated by a shock can be sufficiently energetic to boost, via Inverse Compton (IC) process for example, surrounding soft photons above the rest mass electron energy and thus to trigger the pair creation process. The increase of the associated pair pressure is thus able to disrupt the plasma flow and possib...

objective: the present study was carried out to study the relationship between sensation seeking and social skills in two groups of school age patients down-syndrome (ds) and autism disorder (ds).  methods: this is a descriptive-analytic and correlation study in which all participants were of primary school age (10 to 13 years) with down-syndrome and autism disorder of autism spectrum disorder ...

conclusion the low prevalence of the nb absence in normal fetuses in the present study is compatible with the larger size of the nb in iranian people compared to other communities. meanwhile, the reference range of the nb length in normal iranian fetuses was established so that basic data could be recorded for further studies regarding the absence or presence of the nb in screening for chromoso...

background and objectives: the prevalence of diabetes mellitus (insulin resistance) in individuals with down's syndrome is more than healthy people, which is possibly because of the high prevalence of obesity among them. adiponectin is one of adipose tissue-secreted adipocytokines, which plays a role in pathogenesis of obesity and insulin resistance. this study was carried out with the aim of d...

the photoanthropometric method was used to study the facial features in 136 iranian children with down syndrome, aged 4 to 14 years. nineteen parameters were investigated and compared to an age related control group of 100 normal iranian children. the obtained measurements were related to reference values in the same faces. the normal range was defined by age related index values between the 20...

objectives: down syndrome is the most common chrosomal disorder in which the fine and gross motor skills due to lack of proper sensory experience are disturbed. the role of dexterity in activity of daily living, interaction with environment and independency is quiet crucial in down syndrome. therefore, the aim of this study was to investigate the effects of simultaneous application of superfici...

Abstract Background Atractylodes chinensis (DC.) Koidz is a well-known medicinal plant containing the major bioactive compound, atractylodin, sesquiterpenoid. High-performance liquid chromatography (HPLC) analysis demonstrated that atractylodin was most abundant in 3-year old A. rhizome, compared with those from 1- and 2-year rhizomes, however, molecular mechanisms underlying accumulation of rh...