Accurate total-energy calculations are used to study the structures and formation energies of oxygen chains as models for thermal double donors (TDD's) in Si. We find that the first three TDD's (TDD0-TDD2) consist of one four-member ring, with one or two adjacent interstitial O atoms. These metastable TDD's form bistable negative-U systems with the corresponding stable, electrically inactive st...

BACKGROUND Defects caused by excision of benign lid margin tumors are conventionally repaired by reconstructive surgery. However, second intention healing is another option for managing wounds on the lid margin. OBJECTIVE To evaluate the effectiveness of second intention healing after a shave excision of benign tumors on the lid margin. METHODS Lid defects following a shave excision of the ...

FOREWORD One of the most exciting new trends in water quality management today is the movement by many cities, counties, states, and private-sector developers toward the increased use of Low Impact Development (LID) to help protect and restore water quality. LID comprises a set of approaches and practices that are designed to reduce runoff of water and pollutants from the site at which they are...

Parkinson’s disease (PD) is a neurodegenerative movement disorder characterised by the motor features of tremor, rigidity and bradykinesia. These features are associated with the loss of dopaminergic (DA) neurons in the substantia nigra pars compacta and a subsequent deficiency in striatal DA, which is required for the effective control of movements. However, there is evidence of a more diffuse...

Pancreatic triglyceride lipase (PTL) and the homologous pancreatic lipase related protein 2 (PLRP2) provide a unique opportunity to understand the molecular mechanism of lipolysis. They differ in substrate specificity, sensitivity to bile salts, and colipase dependence despite their close amino acid and tertiary structure identity. One important structure, present in both lipases, is the lid wh...

Numerous biomolecular interactions involve unstructured protein regions, but how to exploit such interactions to enhance the affinity of a lead molecule in the context of rational drug design remains uncertain. Here clarification was sought for cases where interactions of different ligands with the same disordered protein region yield qualitatively different results. Specifically, conformationa...

The type 1 cannabinoid receptor (CB1) is a crucial modulator of synaptic transmission in brain and has been proposed as a potential therapeutic target in Parkinson's disease (PD), especially for treatment of levodopa-induced dyskinesias (LID). Our aim was to measure CB1 levels in brains of PD patients in vivo and to investigate the relation between CB1 availability and LID. We studied 12 health...

Experiment E04-113 at Jefferson Lab Hall C plans to measure the beam-target double-spin asymmetries in semi-inclusive deep-inelastic ~ p(e, eh)X and ~ d(e, eh)X reactions (h = π, π,K orK) with a 6 GeV polarized electron beam and longitudinally polarized NH3 and LiD targets. The high statistic data will allow a spin-flavor decomposition in the region of x = 0.12 ∼ 0.41 at Q = 1.21 ∼ 3.14 GeV. Es...