The effect of exposure to diesel exhaust particulate (DEP) on bacillus Calmette-Guerin (BCG) lung infection in mice was studied. C57Bl/6J female mice were infected with BCG (2.5 x 104 bacteria/mouse) by intrapulmonary instillation, with or without coadministration of DEP (100 microg/mouse). Five weeks later, mice exposed to DEP + BCG had about a four-fold higher BCG load in the lungs than mice ...

BACKGROUND Diesel exhaust particle (DEP) exposure enhances allergic inflammation and has been linked to the incidence of asthma. Oxidative stress on the thiol molecules cysteine (Cys) and glutathione (GSH) can promote inflammatory host responses. The effect of DEP on the thiol oxidation/reduction (redox) state in the asthmatic lung is unknown. OBJECTIVE To determine if DEP exposure alters the...

The contributing role of environmental factors to the development of Parkinson’s disease has become increasingly evident. We report that mesencephalic neuron-glia cultures treated with diesel exhaust particles (DEP; 0.22 μM) (5–50 μg/ml) resulted in a dose-dependent decrease in dopaminergic (DA) neurons, as determined by DA-uptake assay and tyrosine-hydroxylase immunocytochemistry (ICC). The se...

The Ant Colony Optimization (ACO) metaheuristic is a bio-inspired approach for hard combinatorial optimization problems for stationary and non-stationary environments. In the ACO metaheuristic, a colony of artificial ants cooperate for finding high quality solutions in a reasonable time. An interesting example of a non-stationary combinatorial optimization problem is the Multiple Elevators Prob...

This paper discussed the implementation ideas and experimental procedures to solve an engineering related combinatorial problem using DNA computing approach. An elevator scheduling problem is chosen as a benchmark where all the elevator traveled paths are represented by DNA sequence of specific length that represent the elevator’s traveling time in a proportional way based on certain initial co...

Purpose of the study. Reveal typical disorders nutritional status and identify characteristic physical development patients with cerebral palsy. Materials methods. The features 128 children various forms palsy 20 healthy aged 3 to 14 years were studied. Physical was assessed using standard public anthropometric parameters: weight, height, measurement circumference upper lower extremities, deter...

Signal transduction of FMS-like tyrosine kinase 3 (FLT3) is regulated by protein-tyrosine phosphatases (PTPs). We recently identified the PTP DEP-1/CD148/PTPRJ as a novel negative regulator of FLT3. This study addressed the role of DEP-1 for regulation of the acute myeloid leukemia (AML)-related mutant FLT3 internal tandem duplication (ITD) protein. Our experiments revealed that DEP-1 was expre...

The Automated Product Delivery System (APDS) was developed to address a need in industrial manufacturing for a simple way to transfer materials between areas of a manufacturing environment. At the moment, most equipment used for such a task consist of some type of fixed system, such as conveyor belts, elevators, etc. While adequate, they are not easily adaptable to any changes in their environm...