The neuropeptide somatostatin—a cyclic tetradecapeptide first isolated from ovine hypothalamus (1)—is the most widely distributed of the hypothalamic releasing hormones in the central nervous system and in the periphery, including the pancreas, gut, and pituitary. In the brain, somatostatin is believed to function as a neurotransmitter and neuromodulator (2). The effect of somatostatin in the p...

Cerenkov luminescence imaging (CLI) has been recently proposed as a method to visualize surgical margins in the operating theater, immediately after resection, allow refining surgery single procedure. Our group is preparing pilot clinical study evaluate impact of CLI during hepatic metastasectomy, using 18 F-FDG and 68 Ga-DOTATOC. Currently, we are optimizing protocol terms patient inclusion cr...

Neuroendocrine tumours (NETs) constitute a heterogeneous group of tumours that frequently express cell membrane-specific peptide receptors, such as somatostatin receptors (SSTRs), and of which gastroenteropancreatic (GEP), carcinoid and pancreatic islet cell tumours exhibit the highest expression of SSTRs. Radiolabelled receptor-binding somatostatin analogues (octreotide and lanreotide) act as ...

UNLABELLED The (68)Ge/(68)Ga generator provides an excellent source of positron-emitting (68)Ga. However, newly available "ionic" (68)Ge/(68)Ga radionuclide generators are not necessarily optimized for the synthesis of (68)Ga-labeled radiopharmaceuticals. The eluates have rather large volumes, a high concentration of H(+) (pH of 1), a breakthrough of (68)Ge, increasing with time or frequency of...